[Estimation of the intensity of effect of cardenolides. 2: Algorithms for the estimation of the intensity of effect].

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  • Author(s): Köpke K; Dittrich F; Berlin P
  • Source:
    Die Pharmazie [Pharmazie] 1984 Apr; Vol. 39 (4), pp. 256-8.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    German
  • Additional Information
    • Transliterated Title:
      Abschätzung der Wirkstärke von Cardenoliden 2. Mitteilung: Algorithmus zur Abschätzung der Wirkstärke.
    • Source:
      Publisher: Govi-Verlag Pharmazautischer Verlag Country of Publication: Germany NLM ID: 9800766 Publication Model: Print Cited Medium: Print ISSN: 0031-7144 (Print) Linking ISSN: 00317144 NLM ISO Abbreviation: Pharmazie Subsets: MEDLINE
    • Publication Information:
      Publication: Eschborn : Govi-Verlag Pharmazautischer Verlag
      Original Publication: Berlin, Verlag Dr. W. Saenger, [1946-
    • Subject Terms:
      Cardenolides/*pharmacology; Mathematics ; Models, Biological ; Molecular Biology ; Structure-Activity Relationship
    • Abstract:
      An algorithm worked on basis of quantitative relations between molecular-biologically defined effects and molecular-physical properties (see part 1) allows the effect estimation of concepted cardenolides before their synthesis. The empirical use of the developed equations for the estimation of molecular-biologically defined effect of compounds produces usable results and justifies therefore the proposed method, as well as it's shown by the experimental proof of estimated values of some cardenolides . An enlargement of the use of the algorithm for effect estimation seems to be successful.
    • Accession Number:
      0 (Cardenolides)
    • Publication Date:
      Date Created: 19840401 Date Completed: 19840807 Latest Revision: 20070129
    • Publication Date:
      20250114
    • Accession Number:
      6739530