Modeling of the Technological Process for Live Rotavirus Vaccine Production. (English)

We simulate the industrial technology for rotavirus vaccine, based on the strain of group A rotavirus with G1P[8] genotype, circulating among people in Ukraine. We propose to use this strain of rotavirus as the industrial strain. Through successive passages, it is adapted to cultivation conditions in the continuous human and animal cell cultures. The model of technology for the rotavirus vaccine, based on the industrial strain of rotavirus, is developed for its cultivation in continuous cell culture Vero. Specifically, the method of pseudo-suspension cultivation on DEAE Sephadex A-50 microcarriers is used to increase the surface area for cultivation of Vero cells. [ABSTRACT FROM AUTHOR]

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