Effect of season and vitamin D supplementation on plasma concentrations of 25-hydroxyvitamin D in Norwegian infants.

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  • Author(s): Markestad T
  • Source:
    Acta paediatrica Scandinavica [Acta Paediatr Scand] 1983 Nov; Vol. 72 (6), pp. 817-21.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Almquist And Wiksell Country of Publication: Sweden NLM ID: 0000211 Publication Model: Print Cited Medium: Print ISSN: 0001-656X (Print) Linking ISSN: 0001656X NLM ISO Abbreviation: Acta Paediatr Scand Subsets: MEDLINE
    • Publication Information:
      Original Publication: Stockholm : Almquist And Wiksell
    • Subject Terms:
      Seasons*; Hydroxycholecalciferols/*blood ; Vitamin D/*administration & dosage; Breast Feeding ; Female ; Humans ; Infant ; Infant, Newborn ; Norway
    • Abstract:
      Plasma concentrations of 25-hydroxyvitamin D (25OHD) were determined in 81 vitamin D supplemented or unsupplemented infants at the end of winter. The values were compared with maternal levels and with concentrations found in 22 unsupplemented infants at the end of summer. The 25OHD levels of the neonates were lower, but closely related to maternal values (r = 0.95, p less than 0.0005). Unsupplemented breast-fed infants had lower 25OHD levels at 6 weeks than at 4 days (16 +/- 7 vs. 32 +/- 15 nmol/l, mean +/- 1 SD, p less than 0.0005). The mean 25OHD level of vitamin D supplemented 6-12 months old infants was intermediate between those of the unsupplemented nursed groups and the unsupplemented children studied during summer (53 +/- 28 vs. 85 +/- 28 nmol/l, p less than 0.0005). Six weeks old infants who had received a milk formula containing 400 IU vitamin D3 per liter had levels similar to the latter group (92 +/- 21 nmol/l). The data suggest that the vitamin D stores acquired during fetal life, or from ultraviolet light exposure during the summer, may be inadequate to maintain safe levels of 25OHD throughout the winter, but that a daily supplement of 400 IU is adequate to establish concentrations in the summer range.
    • Accession Number:
      0 (Hydroxycholecalciferols)
      1406-16-2 (Vitamin D)
    • Publication Date:
      Date Created: 19831101 Date Completed: 19840508 Latest Revision: 20190821
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/j.1651-2227.1983.tb09822.x
    • Accession Number:
      6673481