Soft tissue volume augmentation by the use of collagen-based matrices in the dog mandible - a histological analysis.

Objectives The aim was to test, whether or not soft tissue volume augmentation with a specifically designed collagen matrix ( CM), leads to ridge width gain in chronic ridge defects similar to those obtained by an autogenous subepithelial connective tissue graft ( SCTG). Material and Methods In six dogs, soft tissue volume augmentation was performed by randomly allocating three treatment modalities to chronic ridge defects [ CM, SCTG and sham-operated control (Control)]. Dogs were sacrificed at 28 ( n = 3) and 84 days ( n = 3). Descriptive histology and histomorphometric measurements were performed on non-decalcified sections. Results SCTG and CM demonstrated favourable tissue integration, and subsequent re-modelling over 84 days. The overall mean amount of newly formed soft tissue ( NMT) plus bone ( NB) amounted to 3.8 ± 1.2 mm (Control), 6.4 ± 0.9 mm ( CM) and 7.2 ± 1.2 mm ( SCTG) at 28 days. At 84 days, the mean NMT plus NB reached 2.4 ± 0.9 mm (Control), 5.6 ± 1.5 mm ( CM) and 6.0 ± 2.1 mm ( SCTG). Statistically significant differences were observed between CM/ SCTG and Control at both time-points ( p < 0.05). Conclusion Within the limits of this animal model, the CM performed similar to the SCTG, based on histomorphometric outcomes combining NB and NMT. [ABSTRACT FROM AUTHOR]

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