Extraezofágový reflux -- otorinolaryngologické komplikácie gastroezofágového refluxu. (Slovak)

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    • Alternate Title:
      Extraesophageal reflux -- otorhinolaryngological complication of gastroesophageal reflux. (English)
    • Abstract:
      Introduction: The aim of this prospective study was evaluated the characteristics of extraesophageal reflux (EER) and comparative analysis of parameters of 24 hours intraesophageal pH monitoring in children with gastroesophageal reflux disease (GERD) and EER. Material and methodes: Study population was consisted of 119 children (30 with GERD, 30 with positive laryngoscopy for EER, 59 with positive otorinolaryngological disorders without positive laryngoscopy). The median age of the patients was 9 years (quartile 60-12 years). Children were underwent 24 hour intraesophageal pH monitoring with two sensors and flexibile laryngoscopy. We collected information about family, personal, allergic and drugs medical history. The Mann-Whitney U test and %2 test were used to assess intergroup comparisons. Results: Children with gastroesophageal reflux had high prevalence of otorinolaryngological disorders. The typical signs of flexibile laryngoscopy (group II) were laryngitis posterior (43.3%). Male sex was often with EER and GERD. The typical symptomps for children with GERD (group I) in comparative to group II and group III were vomiting (18/2, p<0.001) and abdominal pain (24/9, p<0.001) group II, vomiting (18/6, p<0.001) and abdominal pain (24/23, p=0.001) group III. In 24 hours intraesophageal pH monitoring the nocturnal reflux and reflux in supine possition were typical for group I and daytime reflux and reflux in upright possition were predominantly for group II and III. Duration of the longest reflux was longer in pacients with GERD as patients with EER in distal sensor (group I vs. group II17/8, p<0.05, group I vs. group 11,111 17/8, p<0.05). Conclusion: EER is still largely controversial. It is essential to elucidate the molecular basis of pathophysiologic processes with influened the upper esophageal sphincter and the upper airway mucosa and lead to LPR with variation. This could help in discovering of the better diagnostic methods, the treatment and monitoring of EER. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Cieľ štúdie: Prospektívna štúdia s cieľom charakterizovať vlastnosti extraezofágového refluxu (EER) a porovnať jednotlivé parametre 24-hodinovej pH metrie u detí s refluxnou chorobou žalúdka a pažeráka (GERD) a EER. Materiál a metodika: Študovaná populácia pozostávala zo 119 detí (30 detí s GERD, 30 detí s pozitívnym laryngo-skopickým nálezom pre EER, 59 detí s otorinolaryngologickými ochoreniami, ale s negatívnym laryngoskopickým nálezom). Medián veku detských pacientov bol 9,0 roka (kvartil 6-12 roka). Všetky deti podstúpili otorinolaryngologické vyšetrenie flexibilným fibrolaryngoskopom, 24-hodinové pH metrické vyšetrenie a zaznamenali sme anamnestické údaje. Jednotlivé hodnoty sme porovnali pomocou Mannovho-Whitneyho U testu a chi kvadrát testu (%2). Hodnoty p <0,05 vyjadrili štatisticky významný rozdiel medzi porovnávanými hodnotami. Výsledky: Deti s gastroezofágovým refluxom mali vyššiu prevalanciu otorinolaryngologických ochorení. Typickým nálezom flexibilnej fibrolaryngoskopie bola laryngitis posterior (43,3 %). Prevalencia mužského pohlavia bola vyššia u detí s GERD a EER. Typickým prejavom u detí s GERD (skupina I) v porovnaní so skupinami II a III boli vracanie (18/2, p <0,001) a bolesť brucha (24/9, p <0,001) skupina II, vracanie (18/6, p <0,001) a bolesť brucha (24/23, p = 0,001) skupina III. Podl'a 24-hodinovej pH metrie nočný reflux a reflux v polohe v ľahu bol typický v skupine I. Denný reflux a re-flux vo vzpriamenej polohe bol typický pre skupiny II a III. Trvanie najdlhšej refluxnej epizódy bolo dlhšie u pacientov s GERD v porovnaní s pacientami s EER v distálnom senzore (skupina I vs. skupina II 17/8, p <0,05, skupina I vs. skupina 11,111 17/8, p<0,05). Diskusia: V problematike EER je ešte veľa nejasností. Je preto nutné zlepšiť naše znalosti tohto zaujímavého praktického ale aj teoretického problému pomocou d'alších klinických a experimentálnych štúdií. [ABSTRACT FROM AUTHOR]
    • Abstract:
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