Experimental infection of horses with West Nile virus.

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    • Subject Terms:
      MOSQUITO vectors; WEST Nile fever; AEDES albopictus; HORSE diseases; WEST Nile fever transmission; MOSQUITO physiology; BRAIN; BIRDS; RESEARCH; ANIMAL diseases; HORSES; ANIMAL experimentation; SALIVA; DISEASE vectors; RESEARCH methodology; EVALUATION research; WEST Nile virus; COMPARATIVE studies; VIREMIA; VIRAL antibodies; MOSQUITOES; INFECTIOUS disease transmission
    • Abstract:
      A total of 12 horses of different breeds and ages were infected with West Nile virus (WNV) via the bites of infected Aedes albopictus mosquitoes. Half the horses were infected with a viral isolate from the brain of a horse (BC787), and half were infected with an isolate from crow brain (NY99-6625); both were NY99 isolates. Postinfection, uninfected female Ae. albopictus fed on eight of the infected horses. In the first trial, Nt antibody titers reached >1:320, 1:20, 1:160, and 1:80 for horses 1 to 4, respectively. In the second trial, the seven horses with subclinical infections developed Nt antibody titers >1:10 between days 7 and 11 post infection. The highest viremia level in horses fed upon by the recipient mosquitoes was approximately 460 Vero cell PFU/mL. All mosquitoes that fed upon viremic horses were negative for the virus. Horses infected with the NY99 strain of WNV develop low viremia levels of short duration; therefore, infected horses are unlikely to serve as important amplifying hosts for WNV in nature. [ABSTRACT FROM AUTHOR]
    • Abstract:
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