Nucleotide torsional flexibility in solution and the use of the lanthanides as nuclear-magnetic-resonance conformation probes. The case of adenosine 5'-monophosphate.

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  • Author(s): Geraldes CF; Williams RJ
  • Source:
    European journal of biochemistry [Eur J Biochem] 1978 Apr 17; Vol. 85 (2), pp. 463-70.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model: Print Cited Medium: Print ISSN: 0014-2956 (Print) Linking ISSN: 00142956 NLM ISO Abbreviation: Eur J Biochem Subsets: MEDLINE
    • Publication Information:
      Publication: -2004: Oxford, UK : Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
      Original Publication: Berlin, New York, Springer.
    • Subject Terms:
      Adenosine Monophosphate* ; Metals, Rare Earth*; Magnetic Resonance Spectroscopy/methods ; Molecular Conformation ; Ribose
    • Abstract:
      In this article the single family of conformations of adenosine 5'-monophosphate (5'AMP) in aqueous solution previously obtained using the lanthanide ions as nuclear magnetic resonance (NMR) probes is shown to disagree with the conformational data available from independent NMR methods, such as coupling constant and nuclear Overhauser enhancement analysis. The original lanthanide experimental data is reinterpreted assuming the contribution of different conformers to the observed magnetic perturbations. The average conformation obtained for 5'AMP agrees quite satisfactorily with the other independent conformational information.
    • Accession Number:
      0 (Metals, Rare Earth)
      415SHH325A (Adenosine Monophosphate)
      681HV46001 (Ribose)
    • Publication Date:
      Date Created: 19780417 Date Completed: 19780715 Latest Revision: 20190620
    • Publication Date:
      20231215
    • Accession Number:
      10.1111/j.1432-1033.1978.tb12261.x
    • Accession Number:
      648530