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Rifampicin inhibition of protein synthesis in mammalian cells.
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- Author(s): Buss WC; Morgan R; Guttmann J; Barela T; Stalter K
- Source:
Science (New York, N.Y.) [Science] 1978 Apr 28; Vol. 200 (4340), pp. 432-4.
- Publication Type:
Journal Article; Research Support, U.S. Gov't, P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
- Publication Information:
Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
- Subject Terms:
- Abstract:
Rifampicin produces a dose-dependent decrease in protein synthesis in rat thymocytes. At concentrations up to 200 micrograms per milliliter, rifampicin does not alter rat thymic transcription. Rifampicin causes a direct inhibition of protein synthesis in rat thymic and hepatic microsomes, and in cadaveric human hepatic microsomes. Protein synthesis inhibition could explain the toxicity of rifampicin in man.
- Accession Number:
VJT6J7R4TR (Rifampin)
- Publication Date:
Date Created: 19780428 Date Completed: 19780612 Latest Revision: 20211203
- Publication Date:
20240829
- Accession Number:
10.1126/science.644307
- Accession Number:
644307
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