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9 a.m. - 5 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 5 p.m.
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Folly Beach Library
9 a.m. - 2 p.m.
*open the 2nd and 4th Saturday
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Edgar Allan Poe/Sullivan's Island Library
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Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 5 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 5 p.m.
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Otranto Road Library
9 a.m. - 5 p.m.
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Mt. Pleasant Library
9 a.m. – 5 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
9 a.m. - 5 p.m.
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Hurd/St. Andrews Library
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Phone: (843) 805-6930
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Effects of adrenomedullin on the cardiac performance and coronary flow in an isolated perfused rat heart model.
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- Author(s): Amatyakul, Supatra; Patumraj, Suthiluk; Niimi, Hideyuki
- Source:
Clinical Hemorheology & Microcirculation. 2000, Vol. 23 Issue 2-4, p269. 7p.- Subject Terms:
- Source:
- Additional Information
- Abstract: The effect of adrenomedullin (AM) on the cardiac performance and coronary flow were studied in an isolated perfused rat heart model based on the modified Langendorff method. The heart rate (HR), electrocardiogram (ECG), left ventricular contraction (LVC) (dP/dt), and coronary flow (CF) were measured before and after the application of AM. The effect of AM on the coronary flow was examined in the model with and without endothelial degradation, using different inhibitors such as N[sup G]-nitro-L-arginine, glibenclamide, and indomethacin. The present results indicated that AM increased HR and CF, but decreased LVC significantly, while it had no effect on ECG. The vasodilatory effect of AM was discussed in views of endothelial-dependence due to nitric oxide and K[sup +] channel activation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Clinical Hemorheology & Microcirculation is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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