Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians.

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  • Additional Information
    • Source:
      Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
      Original Publication: New Haven [etc.] American Society for Clinical Investigation.
    • Subject Terms:
      Indians, North American* ; Insulin*/pharmacology; Adipose Tissue/*metabolism ; Blood Glucose/*metabolism ; Glucose/*metabolism ; Obesity/*metabolism; Adolescent ; Adult ; Aging ; Arizona ; Biological Transport ; Body Composition ; Calorimetry, Indirect ; Humans ; Male ; Oxygen Consumption
    • Abstract:
      Previous studies have left unanswered whether human obesity, independent of glucose intolerance, is associated with a "postreceptor" defect in insulin action. We have studied the relationship between the degree of obesity (as estimated by underwater weighing) and the maximal insulin-stimulated glucose disposal rate (M) in vivo in 52 glucose-tolerant Pima Indian males. The relationship was examined independently of differences in age and maximal oxygen uptake (an estimate of "physical fitness"). The maximal insulin-stimulated glucose transport rate (MTR) was also measured in isolated abdominal adipocytes from the same subjects to determine whether differences in M could be explained by differences in glucose transport. The results showed that there was a large variance in M and MTR among these glucose-tolerant subjects. M was better correlated with glucose storage rates than with oxidation rates, as estimated by indirect calorimetry. The most obese subjects had only a 20% lower mean M and 30% lower MTR than the most lean subjects. The lower M in the obese subjects was due to both lower glucose oxidation and storage rates. There was no significant, independent correlation between age or degree of obesity and M or MTR. The maximal oxygen uptake (VO2 max) appeared to independently account for 20% of the variance observed in M. MTR was only weakly correlated with M (r = 0.36, P less than 0.02). We concluded that differences in M in these glucose-tolerant subjects must be explained by factor(s) other than maximal oxygen uptake, age, maximal insulin-stimulated glucose transport in vitro, or degree of adiposity per se.
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    • Accession Number:
      0 (Blood Glucose)
      0 (Insulin)
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 19840301 Date Completed: 19840502 Latest Revision: 20181113
    • Publication Date:
      20231215
    • Accession Number:
      PMC425083
    • Accession Number:
      10.1172/JCI111274
    • Accession Number:
      6368588