Analysis of oxime-induced neuromuscular recovery in guinea pig, rat and man following soman poisoning in vitro.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Smith AP; Van der Wiel HJ; Wolthuis OL
  • Source:
    European journal of pharmacology [Eur J Pharmacol] 1981 Mar 26; Vol. 70 (3), pp. 371-9.
  • Publication Type:
    Comparative Study; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Amsterdam : Elsevier Science
      Original Publication: Amsterdam, North Holland Pub. Co.
    • Subject Terms:
      Organophosphate Poisoning*; Neuromuscular Junction/*physiology ; Pralidoxime Compounds/*pharmacology ; Pyridinium Compounds/*pharmacology ; Soman/*poisoning ; Synaptic Transmission/*drug effects; Aged ; Animals ; Diaphragm/drug effects ; Guinea Pigs ; Humans ; In Vitro Techniques ; Intercostal Muscles/drug effects ; Male ; Middle Aged ; Organ Specificity ; Oximes ; Rats ; Species Specificity ; Time Factors
    • Abstract:
      The bispyridinium oximes HS6 and HI6 were tested in vitro for their ability to restore neuromuscular function in soman-poisoned tissue, using diaphragm and intercostal muscle of the rat and guinea pig and intercostal muscle of man. It was found that the oxime-mediated recovery of function in both tissues of the rat and guinea pig was composed of direct oxime actions, AChE reactivation and adaptation. In the human intercostal muscle, however, only adaptation was observed. These findings might suggest that HS6 and HI6 may have only limited value in the treatment of soman poisoning in man. However, recovery of function in rodent tissues was consistently greater in the diaphragm than in the intercostal muscle and, since human diaphragm tissue was not included in this study the therapeutic efficacy of these oximes in this tissue remains unknown.
    • Accession Number:
      0 (Oximes)
      0 (Pralidoxime Compounds)
      0 (Pyridinium Compounds)
      22625-23-6 (HS 6)
      96-64-0 (Soman)
      HUV88P6SJS (asoxime chloride)
    • Publication Date:
      Date Created: 19810326 Date Completed: 19810720 Latest Revision: 20190624
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/0014-2999(81)90170-9
    • Accession Number:
      6262099