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The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer.
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- Additional Information
- Source:
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0222643 Publication Model: Print Cited Medium: Print ISSN: 0022-4790 (Print) Linking ISSN: 00224790 NLM ISO Abbreviation: J Surg Oncol Subsets: MEDLINE
- Publication Information:
Publication: <2005-> : Hoboken, NJ : Wiley-Liss
Original Publication: New York, Plenum.
- Subject Terms:
- Abstract:
A poorly differentiated transitional cell carcinoma in C3H/He mice results from the oral ingestion of the urinary tract carcinogen FANFT. This model, designated MBT2, is readily transplantable into syngeneic animals and has proven to be very useful in the development of chemotherapy. Prior to the use of this model for the testing of potential immunotherapeutic strategies, we have attempted to characterize the immunobiology of this tumor line. We report that the primary growth of this tumor in the footpad and its metastasis to lung are correlated with the development of increased numbers of suppressor cells, characterized by the expression of a surface histamine H2 receptor. These cells are originally evident in spleen and become maximal approximately 4 weeks after tumor implantation. This is followed by the migration of these cells from spleen to peripheral blood, an event that parallels the growth and eventual metastasis of this implanted transitional cell carcinoma. These events may have important significance for the development of immunomodulating therapy against bladder cancer.
- Grant Information:
55077 RR 05487-17 United States RR NCRR NIH HHS; CA 27168 United States CA NCI NIH HHS
- Accession Number:
0 (Receptors, Histamine)
0 (Receptors, Histamine H2)
0 (Thiazoles)
7N99PZG62O (FANFT)
- Publication Date:
Date Created: 19830901 Date Completed: 19831028 Latest Revision: 20190821
- Publication Date:
20231215
- Accession Number:
10.1002/jso.2930240113
- Accession Number:
6224980
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