[Combined treatment with intra-arterial administration of oily anti-cancer agents and transcatheter arterial embolization--clinical and pathological study on 2 cases with resected small hepatoma].

Publisher: Shinohara Publishers Country of Publication: Japan NLM ID: 1257753 Publication Model: Print Cited Medium: Print ISSN: 0021-4949 (Print) Linking ISSN: 00214949 NLM ISO Abbreviation: Gan No Rinsho Subsets: MEDLINE

Publication: Tokyo : Shinohara Publishers
Original Publication: Tokyo, Ishiyaku Shuppan.

Embolization, Therapeutic*/methods; Antibiotics, Antineoplastic/*administration & dosage ; Carcinoma, Hepatocellular/*therapy ; Furans/*administration & dosage ; Iodized Oil/*administration & dosage ; Liver Neoplasms/*therapy ; Maleic Anhydrides/*administration & dosage ; Polystyrenes/*administration & dosage ; Zinostatin/*administration & dosage; Carcinoma, Hepatocellular/pathology ; Hepatic Artery ; Humans ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Zinostatin/analogs & derivatives

Combined treatment with intraarterial administration of oily anti-cancer agent (SMANCS-Lipiodol; copolymer of styrene maleic acid conjugate of Neocarcinostatin disolved in Ethiodol) and transcatheter arterial embolization (TAE) was employed in 2 patients with small hepatoma. At 3-4 weeks after treatment, hepatic resection was performed. Histopathological examination of the 2 resected specimens showed total cell necrosis; CT and Softex revealed the distribution of lipiodol in the tumor and adjacent regions. This combination treatment showed combined effects, i.e. embolization by TAE, the anti-cancer effect of SMANCS and the selective delivery of lipidol to the hepatoma, especially the area of capsula invasion, the daughter nodule and tumor thrombus.

0 (Antibiotics, Antineoplastic)
0 (Furans)
0 (Maleic Anhydrides)
0 (Polystyrenes)
0 (poly(maleic acid-styrene)neocarzinostatin)
8001-40-9 (Iodized Oil)
9014-02-2 (Zinostatin)

Date Created: 19840701 Date Completed: 19841010 Latest Revision: 20061115

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