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Wando Mount Pleasant Library
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T-cell tolerance by dendritic cells and macrophages as a mechanism for the major histocompatibility complex-linked resistance to autoimmune diabetes.
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- Author(s): Thiessen, Shari; Serra, Pan; Amrani, Abdelaziz; Verdaguer, Joan; Santamaria, Pere; Serra, Pau
- Source:
Diabetes; Feb2002, Vol. 51 Issue 2, p325-338, 14p, 1 Color Photograph, 1 Diagram, 2 Charts, 4 Graphs- Subject Terms:
DENDRITIC cells; HISTOCOMPATIBILITY; MACROPHAGES; THYMUS physiology; HEMATOPOIETIC stem cells; ANIMAL experimentation; CELL division; CELL receptors; COMPARATIVE studies; DISEASE susceptibility; HISTOCOMPATIBILITY antigens; IMMUNOLOGICAL tolerance; TYPE 1 diabetes; ISLANDS of Langerhans; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; STATISTICS; T cells; THYMUS; EVALUATION research; PHYSIOLOGY - Source:
- Additional Information
- Abstract: For poorly understood reasons, the development of autoimmune diabetes in humans and mice is dominantly inhibited by major histocompatibility complex (MHC) class II molecules with diverse antigen-binding sites. We have previously shown that thymocytes expressing a highly diabetogenic I-A(g7)-restricted T-cell receptor (TCR) (4.1-TCR) undergo negative selection in mice carrying one copy of the antidiabetogenic H-2(b) haplotype in an I-A(b)-dependent but superantigen-independent manner. Here, we show that 4.1-TCR-transgenic thymocytes undergo different forms of tolerance in NOD mice expressing antidiabetogenic I-A(d), I-A(g7PD), or I-Ealpha(k) transgenes. The ability of protective MHC class II molecules to induce thymocyte tolerance in 4.1-TCR-transgenic NOD mice correlates with their ability to prevent diabetes in non-TCR-transgenic mice and is associated with polymorphisms within positions 56-67 of their beta1 domains. The 4.1-thymocyte tolerogenic activity of these MHC class II molecules is mediated by dendritic cells and macrophages but not by B-cells or thymic epithelial cells and is a peptide-dependent process. Antidiabetogenic MHC class II molecules may thus afford diabetes resistance by presenting, on dendritic cells and macrophages, tolerogenic peptides to a subset of highly diabetogenic and MHC-promiscuous CD4(+) T-cells that play a critical role in the initiation of diabetes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Diabetes is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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