[Development of arrangement and degradation of the system of rough endoplasmic reticulum in antibody-producing plasma cells].

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  • Author(s): Hajdu I; Hofman J
  • Source:
    Ceskoslovenska patologie [Cesk Patol] 1977 May; Vol. 13 (1-2), pp. 44-51.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      Vývoj usporádání degradace systému hrubého endoplazmatického retikula v plazmatických bunkách tvorících protilátky.
    • Source:
      Publisher: Ceska Lekarska Spolecnost Country of Publication: Czech Republic NLM ID: 0050734 Publication Model: Print Cited Medium: Print ISSN: 1210-7875 (Print) Linking ISSN: 12107875 NLM ISO Abbreviation: Cesk Patol Subsets: MEDLINE
    • Publication Information:
      Publication: Praha : Ceska Lekarska Spolecnost
      Original Publication: Praha : Státní zdravotnické nakladatelství, 1965-
    • Subject Terms:
      Antibody Formation/*drug effects ; Endoplasmic Reticulum/*immunology ; Plasma Cells/*immunology; Animals ; Cell Differentiation/drug effects ; Female ; Mice ; Mitogens/pharmacology ; Omentum/immunology ; Ribosomes/immunology
    • Abstract:
      During the immune response of the cells of murine omentum to horseradish peroxidase which had been administered intraperitoneally together together with endotoxin or endotoxoid acting as an adjuvans the plasma cells showed several different patterns of the rough endoplasmic reticulum [RER] system. Irregular to bizarre RER structures occurred plasma cells during the initial phase of the immune reaction only, whereas the plasma cells found at later stages had characteristic highly organized RER systems. The irregular "atypical" RER patterns have been regarded by some authorities as fully functional structures developed under the influence of a rapid differentiation of immunocompetent cells following administration of mitogens as well as due to a variously pronounced toxic influence of mitogens upon cell organelles. The possibilities of RER system degradation and the fate of antibodies which had not been discharged by the plasma cells has been discussed.
    • Accession Number:
      0 (Mitogens)
    • Publication Date:
      Date Created: 19770501 Date Completed: 19780310 Latest Revision: 20160510
    • Publication Date:
      20221208
    • Accession Number:
      597922