Localization of d-serine and serine racemase in neurons and neuroglias in mouse brain.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Subject Terms:
      SERINE proteinases; NEURONS; LABORATORY mice; METHYL aspartate; BRAIN function localization; NEUROTRANSMITTERS; ASTROCYTES
    • Abstract:
      d-Serine is a novel candidate for an intrinsic ligand for the glycine site of N-methyl- d-aspartate (NMDA) receptors in mammalian brain. d-Serine and serine racemase, which produces d-serine from l-serine, have long been presumed to be localized in astrocytes. However, we have reported that d-serine immunoreactivity was observed in neurons in rats. In the present study, the distributions of d-serine and serine racemase were investigated in combination with marker proteins for neurons, astrocytes and oligodendrocytes in mice. Immunoreactivities for d-serine and serine racemase were found in neurons and oligodendrocytes. These results suggest that d-serine can be produced in neurons as well as glias and used as a neurotransmitter, which control the synaptic function of NMDA receptors. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)