Resolution and repair of elastic tissue calcification in pseudoxanthoma elasticum.

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  • Additional Information
    • Source:
      Publisher: College of American Pathologists Country of Publication: United States NLM ID: 7607091 Publication Model: Print Cited Medium: Print ISSN: 0003-9985 (Print) Linking ISSN: 00039985 NLM ISO Abbreviation: Arch Pathol Lab Med Subsets: MEDLINE
    • Publication Information:
      Publication: Northfield, Ill. : College of American Pathologists
      Original Publication: Chicago, American Medical Assn.
    • Subject Terms:
      Calcinosis/*pathology ; Elastic Tissue/*pathology ; Pseudoxanthoma Elasticum/*pathology ; Skin/*pathology; Biopsy ; Calcinosis/etiology ; Child ; Female ; Humans ; Pseudoxanthoma Elasticum/complications ; Remission, Spontaneous
    • Abstract:
      Biopsy specimens of a skin lesion from a patient with pseudoxanthoma elasticum were obtained at the beginning and end of a 1 1/2-year period of clinically documented regression of the lesion. Light microscopic studies of these specimens showed that, during the period of regression, there was a decrease in the number of abnormal calcified elastic fibers in the dermis. Electron microscopic findings were interpreted as indicating breakdown and removal of mineralized elastic fibers at the beginning and formation of new elastic fibers at the end of the regression period. Cytoplasmic processes of active fibroblasts were intimately associated with fibers undergoing dissolution. The case thus represents a clinically and morphologically documented example of resolution and repair of elastic tissue calcification.
    • Publication Date:
      Date Created: 19780601 Date Completed: 19780715 Latest Revision: 20041117
    • Publication Date:
      20240829
    • Accession Number:
      580723