[Therapy of a refractory idiopathic thrombocytopenic purpura by vinblastine-loaded thrombocytes (author's transl)].

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  • Author(s): Budde U; Schmidt R; Gerloff J; Etzel F
  • Source:
    Blut [Blut] 1979 Feb 19; Vol. 38 (2), pp. 139-41.
  • Publication Type:
    Case Reports; English Abstract; Journal Article
  • Language:
    German
  • Additional Information
    • Transliterated Title:
      Therapie einer refraktären idiopathisch-thrombozytopenischen Purpura mit Vinblastin-beladenen Thrombozyten.
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0173401 Publication Model: Print Cited Medium: Print ISSN: 0006-5242 (Print) Linking ISSN: 00065242 NLM ISO Abbreviation: Blut Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin : Springer Verlag
    • Subject Terms:
      Blood Platelets*; Purpura, Thrombocytopenic/*drug therapy ; Vinblastine/*therapeutic use; Adolescent ; Humans ; Male ; Vinblastine/administration & dosage ; Vinblastine/adverse effects
    • Abstract:
      A 15-year-old patient with ITP which was refractory to corticosteroids, splenectomy, and immunosuppressive therapy with vincristine was twice treated with platelets loaded with vinblastine. Five days after the application of the platelets vinblastine complex the platelets began to rise up to 600 X 10(9)/l. The remission has lasted until now for more than 15 weeks. The therapy showed no major side effects except for a transient granulocytopenia.
    • References:
      Annu Rev Med. 1977;28:299-309ENG. (PMID: 324364)
      N Engl J Med. 1974 Aug 22;291(8):376-80. (PMID: 4847353)
      Am J Med. 1974 Jan;56(1):4-12. (PMID: 4855619)
      N Engl J Med. 1978 May 18;298(20):1101-7. (PMID: 565464)
    • Accession Number:
      5V9KLZ54CY (Vinblastine)
    • Publication Date:
      Date Created: 19790219 Date Completed: 19790426 Latest Revision: 20190902
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/BF01007955
    • Accession Number:
      570071