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The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study.
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- Author(s): Lambert, Jean-Charles; Sleegers, Kristel; González-Pérez, Antonio; Ingelsson, Martin; Beecham, Gary W.; Hiltunen, Mikko; Combarros, Onofre; Bullido, Maria J.; Brouwers, Nathalie; Bettens, Karolien; Berr, Claudine; Pasquier, Florence; Richard, Florence; DeKosky, Steven T.; Hannequin, Didier; Haines, Jonathan L.; Tognoni, Gloria; Fiévet, Nathalie; Dartigues, Jean-François; Tzourio, Christophe
- Source:
Journal of Alzheimer's Disease; 2010, Vol. 22 Issue 1, p247-255, 9p, 2 Charts, 1 Graph- Subject Terms:
- Source:
- Additional Information
- Abstract: The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ℇ4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ℇ4 allele of the APOE gene. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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