NEALKOHOLNA BOLEST MASNE JETRE KAO POSLJEDICA PROFESIONALNE IZLOŽENOSTI ORGANSKIM OTAPALIMA.

NONALCOHOLIC FATTY LIVER DISEASE AS A RESULT OF OCCUPATIONAL EXPOSURE TO ORGANIC SOLVENTS.

Recent epidemiological studies indicate that occupational exposure to organic solvents may be an independent risk factor for the development of nonalcoholic fatty liver disease (NAFLD), particularly if occupational exposure limits are exceeded. Clinical assessment of hepatotoxicity of industrial solvents must take into account synergism with metabolic risk factors, but also other factors like medications, alcohol, viruses, age and nutrition. If occupational exposure to solvents remains within the permissible limits NAFLD may still develop as a work-related disease. It is essential that liver function testing is included in the periodic medical assessment of solvent-exposed workers, and that high risk individuals are identified and excluded from further exposure in order to prevent the development of irreversible liver damage. [ABSTRACT FROM AUTHOR]

Prema novijim istraživanjima izloženost organskim otapalima na radnom mjestu je mogući neovisni čimbenik rizika za razvoj nealkoholne bolesti masne jetre (NAFLD), posebno ako izloženost prelazi zakonski propisane granične vrijednosti. Kod kliničke procjene oštećenja jetre zbog izloženosti otapalima valja uzeti u obzir sinergizam prvenstveno s metaboličkim, ali i drugim čimbenicima rizika, kao što su lijekovi, alkohol, virusi, životna dob i prehrana. U uvjetima izloženosti dopuštenim koncentracijama organskih otapala NAFLD se može razviti kao bolest vezana uz rad. U izloženoj radnoj populaciji potrebna je redovita zdravstvena kontrola funkcije jetre, te pravovremen odabir posebno rizičnih osoba i njihovo isključivanje iz daljnje izloženosti otapalima kako bi se spriječila moguća trajna oštećenja. [ABSTRACT FROM AUTHOR]

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