Histaminergic Influence on Vestibular Stimulation-induced Locus Coeruleus Inhibition in Rats.

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    • Subject Terms:
      HISTAMINERGIC mechanisms; LOCUS coeruleus; VESTIBULAR apparatus physiology; RAT physiology; PHYSIOLOGY
    • Abstract:
      In previous reports we have shown that caloric stimulation (CS) of the vestibular apparatus inhibits locus coeruleus (LC)-noradrenergic neuronal activity in urethane-anaesthetized rats. The present study examined the effect of neural histamine depletion by α-fluoromethylhistidine (α-FMH) on CS-induced LC inhibition. In α-FMH treated rats, LC neuronal inhibition caused by CS was still observed. This finding indicates that the central histaminergic neuron system does not participate in the CS-induced LC-noradrenergic inhibition. It is suggested that the noradrenergic neuron system is involved in the development of vestibulo-autonomic response, independent of the histaminergic neuron system. [ABSTRACT FROM AUTHOR]
    • Abstract:
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