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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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St. Paul's/Hollywood Library
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Otranto Road Library
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McClellanville Library
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John's Island Library
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Miss Jane's Building (Edisto Library Temporary Location)
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The Pathological Cross Talk Between Apolipoprotein E and Amyloid-β Peptide in Alzheimer's Disease: Emerging Gene-Based Therapeutic Approaches.
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- Author(s): Iurescia, Sandra; Fioretti, Daniela; Mangialasche, Francesca; Rinaldi, Monica
- Source:
Journal of Alzheimer's Disease; 2010, Vol. 21 Issue 1, p35-48, 14p, 4 Diagrams- Subject Terms:
- Source:
- Additional Information
- Abstract: Apolipoprotein E (ApoE) plays a key role in lipid transport in the plasma and in the central nervous system through its interaction with members of the low-density lipoprotein receptor family. The three common isoforms of ApoE (ApoE2, ApoE3, and ApoE4) differ in their ability to perform neuronal maintenance and repair functions and differentially affect the risk of developing neurodegenerative disorders. The ApoE4 isoform is a strong genetic risk factor for Alzheimer's disease. Up-to-date knowledge about the structural and biophysical features of ApoE4 shed light on the molecular basis underlying the isoform-specific pathogenic role of ApoE4 and its contribution to AD pathology through several different mechanisms. ApoE4 impacts on amyloid-β (Aβ) production, Aβ clearance, Aβ fibrillation, and tangle formation as well as on mitochondrial functions leading to neuronal toxicity and synaptic damage. This review summarizes the pathological cross talk between ApoE and Aβ peptide in Alzheimer's disease. Lastly, we examine emerging gene-based therapeutic approaches encompassing the use of ApoE and their potential opportunities to preventing or treating Alzheimer's disease. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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