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Bir Şizofreni Hastasında Klozapin Tedavisine Modafinil Eklenmesi ile Ortaya Çıkan Hipomani. (Turkish)
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- Additional Information
- Alternate Title:
Hypomania in a Schizophrenic Patient Treated with Modafinil for Clozapine- Induced Sedation. (English)
- Abstract:
Modafinil is used in the treatment of excessive daytime sleepiness associated with several conditions. Modafinil has also been suggested to improve antipsychotic-associated sedation in patients with schizophrenia. Although a small risk of psychosis exacerbation has been reported due to modafinil adjunct treatment, modafinil-induced mania or hypomania has not been described in schizophrenia up to now. Herein, we present a 31-year-old patient diagnosed as having schizophrenia according to DSM-IV-TR, who developed a hypomanic episode with irritability, motor activation and uninterruptible speech soon after adding modafinil to clozapine. In this context, the risks and benefits of adjunct therapy with modafinil in treatment- resistant schizophrenic patients who have been prescribed clozapine will be discussed. [ABSTRACT FROM AUTHOR]
- Abstract:
Modafinil gündüz uykululuğu ile giden klinik durumların tedavisinde kullanılmaktadı r. Şizofrenide antipsikotiklere bağlı gelişen uykululuk yan etkisini azaltmak için de kullanılabileceği öne sürülmüştür. Şizofrenide modafinil eklenmesi ile psikozda hafif bir kötüleşme olabildiği bilinmekle birlikte, şu ana kadar manik-hipomanik uyarılma bildirilmemiştir. Bu yazıda DSM-IV-TR'ye göre şizofreni tanısı konan 31 yaşında bir hastada, klozapinin uykululuk yan etkisini tedavi etmek üzere eklenen modafinille ortaya çıkan bir hipomani tablosu sunulacaktır. Bu olgu sunumu bağlamında şizofrenide tedaviye dirençli hastalarda etkin bir antipsikotik olan klozapine modafinil eklenmesi, risk ve yarar dengesi açısından tartışılacaktır. [ABSTRACT FROM AUTHOR]
- Abstract:
Copyright of Archives of Neuropsychiatry / Nöropsikiyatri Arşivi is the property of Turkish Association of Neuropsychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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