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Wando Mount Pleasant Library
Closed for Staff Day
Phone: (843) 805-6888
Village Library
Closed for Staff Day
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed for Staff Day
Phone: (843) 889-3300
Otranto Road Library
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Phone: (843) 572-4094
Mt. Pleasant Library
Closed for Staff Day
Phone: (843) 849-6161
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Folly Beach Library
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Dorchester Road Library
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John L. Dart Library
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Phone: (843) 722-7550
Baxter-Patrick James Island
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Main Library
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Bees Ferry West Ashley Library
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Miss Jane's Building (Edisto Library Temporary Location)
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An autism cohort study of cobalt levels following vitamin B12 injections.
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- Author(s): Geier, David A.1,2; Geier, Mark R.3,4
- Source:
Toxicological & Environmental Chemistry. May2010, Vol. 92 Issue 5, p1025-1037. 13p.- Subject Terms:
- Source:
- Additional Information
- Abstract: The effects of methylcobalamin (vitamin B12) injection (75 µg kg-1) on cobalt levels in autism spectrum disorders (ASDs) and potential toxic effects of cobalt on human neurons were evaluated. A cohort of ASDs (n = 72) presenting to the Genetic Centers of America were evaluated for the frequency of methylcobalamin injections and cobalt levels using Laboratory Corporation of America (LabCorp) testing. Potential toxic effects of cobalt (cobalt(II) nitrate hexahydrate) to human neurons grown in vitro were evaluated. Methylcobalamin injections significantly increased the mean levels of plasma cobalt (6.83-fold) and urinary cobalt (51-fold) in comparison to unexposed subjects, and significant positive correlations were found between the frequency of methylcobalamin injections and the levels of plasma and urinary cobalt (injections every second day induced cobalt levels in excess of the LabCorp cobalt occupational maximum exposure limits). The LC50 in human neurons following 24 h incubation with cobalt is 559 µM. Research must be conducted to determine optimal therapeutic methylcobalamin doses. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Toxicological & Environmental Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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