Effect of glucocorticoid levels in vivo on growth hormone biosynthesis.

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  • Author(s): Brattin WJ; Portanova R
  • Source:
    Molecular and cellular endocrinology [Mol Cell Endocrinol] 1979 Jul; Vol. 15 (1), pp. 19-27.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print Cited Medium: Print ISSN: 0303-7207 (Print) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : North Holland Publishing
      Original Publication: Amsterdam, North-Holland.
    • Subject Terms:
      Glucocorticoids/*physiology ; Growth Hormone/*biosynthesis; Adrenalectomy ; Animals ; Corticosterone/pharmacology ; Cortisone/pharmacology ; Dexamethasone/pharmacology ; Hydrocortisone/pharmacology ; Pituitary Gland/drug effects ; Pituitary Gland/metabolism ; Rats ; Triamcinolone/pharmacology
    • Abstract:
      The rate of growth hormone (GH) biosynthesis in pituitary cells prepared from rats with different histories of glucocorticoid exposure was analyzed by a dual-labeling acrylamide-gel technique. Glucocorticoid deficiency, produced by adrenalectomy, reduces GH synthesis by approximately 50%. GH synthesis adrenalectomized rats treated with either natural or synthetic glucocorticoids, is restored to normal or above normal levels. Acute exposure (1 h) of cells to corticosterone in vitro does not produce a significant increase in GH synthesis. Adrenalectomized rats treated with steroid for one day show a small but detectable increase in GH synthesis, while treatment for 3--6 days results in progressively larger stimulatory effects. All of these results are similar to previous findings regarding glucocorticoid stimulation of GH synthesis in vitro.
    • Accession Number:
      0 (Glucocorticoids)
      1ZK20VI6TY (Triamcinolone)
      7S5I7G3JQL (Dexamethasone)
      9002-72-6 (Growth Hormone)
      V27W9254FZ (Cortisone)
      W980KJ009P (Corticosterone)
      WI4X0X7BPJ (Hydrocortisone)
    • Publication Date:
      Date Created: 19790701 Date Completed: 19791227 Latest Revision: 20190813
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/0303-7207(79)90067-4
    • Accession Number:
      488525