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Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits.
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- Author(s): Buckholtz, Joshua W.; Treadway, Michael T.; Cowan, Ronald L.; Woodward, Neil D.; Benning, Stephen D.; Rui Li; Ansari, M. Sib; Baldwin, Ronald M.; Schwartzman, Ashley N.; Shelby, Evan S.; Smith, Clarence E.; Cole, David; Kessler, Robert M.; Zald, David H.
- Source:
Nature Neuroscience. Apr2010, Vol. 13 Issue 4, p419-421. 3p. 2 Graphs.
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- Abstract:
Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [18F]fallypride positron emission tomography and blood oxygen level–dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy. [ABSTRACT FROM AUTHOR]
- Abstract:
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