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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Otranto Road Library
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Hurd/St. Andrews Library
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Low-Level CD4+ T Cell Activation in HIV-Exposed Seronegative Subjects: Influence of Gender and Condom Use.
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- Author(s): Camara, Makhtar; Dieye, Tandakha Ndiaye; Seydi, Moussa; Diallo, Abdoul Aziz; Fall, Marema; Diaw, Papa Alassane; Sow, Papa Salif; Mboup, Souleymane; Kestens, Luc; Jennes, Wim
- Source:
Journal of Infectious Diseases; 3/15/2010, Vol. 201 Issue 6, p835-842, 8p, 3 Charts, 3 Graphs- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Immune activation has been suggested to increase susceptibility to human immunodeficiency virus type 1 (HIV-1) transmission, while at the same time it could be deemed essential for mounting an effective antiviral immune response. In this study, we compared levels of T cell activation between exposed seronegative (ESN) partners in HIV-1 discordant couples and HIV-unexposed control subjects in Dakar, Senegal. ESN subjects showed lower levels of CD38 expression on CD4+ T cells than did control subjects. However, this was found to be associated with concurrent differences in the use of condoms: ESN subjects reported a higher degree of condom use than did control subjects, which correlated inversely with CD38 expression. In addition, we observed markedly higher levels of T cell activation in women compared with men, irrespective of sexual behavior. These findings question the relevance of low-level CD4+ T cell activation in resistance to HIV-1 infection and underscore the need to take gender and sexual behavior characteristics of high-risk populations into account when analyzing correlates of protective immunity. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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