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Association of homozygous SDF-1 3′A genotype with proliferative diabetic retinopathy.
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- Author(s): Djuric, Zdenka; Sharei, Vahid; Rudofsky, Gottfried; Morcos, Michael; Huiqing Li; Hammes, Hans-Peter; Nawroth, Peter P.; Bierhaus, Angelika; Humpert, Per M.; Jonas, Jost B.
- Source:
Acta Diabetologica; Mar2010, Vol. 47 Issue 1, p79-82, 4p, 3 Charts- Subject Terms:
- Source:
- Additional Information
- Abstract: Stromal cell-derived factor 1 (SDF-1) is involved in the development of experimental proliferative retinopathy. Since little data are available on the genetic predisposition or on biomarkers predicting the development of proliferative retinopathy, we assessed the distribution of the SDF-1 3′A genotype in 130 diabetic patients with retinopathy. In patients with proliferative retinopathy, the frequency of the homozygous SDF-1 3′A genotype was significantly higher than in patients with non-proliferative retinopathy (10.9% of PDR vs. 0 of NPDR, P = 0.01). This association was confirmed when type 2 diabetes patients were analysed separately (10.3% of PDR vs. 0 of NPDR, P = 0.03). The finding that homozygous carriers of the SDF-1 3′A genotype are more frequent in diabetes patients with proliferative retinopathy suggests a possible role of this genotype in the development of sight-threatening diabetic retinopathy. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Acta Diabetologica is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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