The kinetics of serum and tissue ferritins: relation to carbohydrate content.

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  • Author(s): Halliday JW; Mack U; Powell LW
  • Source:
    British journal of haematology [Br J Haematol] 1979 Aug; Vol. 42 (4), pp. 535-46.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print Cited Medium: Print ISSN: 0007-1048 (Print) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: Oxford : Blackwell Scientific Publications
    • Subject Terms:
      Carbohydrates/*blood ; Ferritins/*blood; Animals ; Apoferritins/blood ; Ferritins/isolation & purification ; Ferritins/metabolism ; Half-Life ; Iron/metabolism ; Kidney/metabolism ; Liver/metabolism ; Male ; Myocardium/metabolism ; Rats ; Tissue Distribution
    • Abstract:
      Significant differences were observed in the rate of disappearance from plasma of ferritins purified from rat serum and from different organs. Ferritin from all sources including purified serum ferritin was rapidly removed from plasma by the liver. No difference in biological half-life was observed between apoferritin prepared by ultracentrifugation of liver ferritin and whole liver ferritin and iron-loaded animals cleared injected serum ferritin from plasma at a comparable rate to normal rats. When amounts of 100 microgram of ferritin were injected into rats the half-life was significantly lengthened. The study confirmed the fact that ferritin iron and ferritin protein were removed from plasma at the same rate. No consistent effect of acidic or more basic isoferritin composition on biological half-life was apparent. After chromatography on concanavalin A-Sepharose 6B those ferritins which were predominantly bound to Con A-Sepharose had a half-life which was approximately twice that of ferritins which did not bind. It is concluded that the variation in plasma disappearance of ferritins of different tissue origin was explainable on the basis of carbohydrate content of the molecule.
    • Accession Number:
      0 (Carbohydrates)
      9007-73-2 (Ferritins)
      9013-31-4 (Apoferritins)
      E1UOL152H7 (Iron)
    • Publication Date:
      Date Created: 19790801 Date Completed: 19791129 Latest Revision: 20190704
    • Publication Date:
      20221213
    • Accession Number:
      10.1111/j.1365-2141.1979.tb01166.x
    • Accession Number:
      476005