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Metastasis: Self-renewal migrates onwards.
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- Author(s): McCarthy, Nicola
- Source:
Nature Reviews Cancer. Jan2010, Vol. 10 Issue 1, p6-7. 2p. 1 Color Photograph.
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- Additional Information
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- Abstract:
The article discusses the research of Thomas Brabletz and colleagues regarding the epithelial to mesenchymal transition (EMT) of the cancer cells. It notes the metastasis of the cancer cells was due to the misregulation of TWIST, SNAI1 and ZEB1, and microRNAs that regulate stem cell characteristics such as the mir-200c family. The research shows that the expression of ZEB1 enables both EMT and stem cell characteristics of the cancer cells to proliferate.
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