A critical assessment of the mechanism by which hyperoxia attenuates exercise-induced asthma.

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  • Author(s): Resnick AD; Deal EC Jr; Ingram RH Jr; McFadden ER Jr
  • Source:
    The Journal of clinical investigation [J Clin Invest] 1979 Aug; Vol. 64 (2), pp. 541-9.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
      Original Publication: New Haven [etc.] American Society for Clinical Investigation.
    • Subject Terms:
      Body Temperature Regulation* ; Oxygen* ; Respiration* ; Respiratory Function Tests*; Asthma/*physiopathology ; Asthma, Exercise-Induced/*physiopathology; Adult ; Airway Resistance ; Bronchial Spasm/physiopathology ; Female ; Forced Expiratory Volume ; Humans ; Humidity ; Male ; Residual Volume ; Temperature ; Tidal Volume ; Total Lung Capacity
    • Abstract:
      Recent data demonstrate that the magnitude of the heat loss that occurs from the respiratory tract during exercise correlates with the degree of post-exertional obstruction that develops in asthmatics. Respiratory heat loss relates directly to the minute ventilation and heat capacity of the inspired gas and inversely to its water content and temperature. Because it has been shown that inhaling 100% oxygen during exercise blunts the obstructive response, we wondered if this effect could be accounted for by differing values of heat exchange with air and oxygen breathing. To examine this question, we studied 10 asthmatics by measuring multiple aspects of pulmonary mechanics before and after four bouts of exhausting leg work during which the subjects inhaled either air or oxygen conditioned to provide widely differing thermal burdens on their airways. Under all inspired gas conditions, oxygen breathing produced significantly less obstruction than air. Minute ventilation was also significantly less with oxygen as was the total heat lost. As the latter fell, so did the magnitude of the postexercise obstruction. When the differences in ventilation and respiratory heat loss between air and oxygen were eliminated by eucapnic hyperventilation, the differences in the obstructive responses also disappeared. Thus, the effects of hyperoxia on exercise-induced asthma can be accounteed for solely by alterations in heat exchange.
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    • Accession Number:
      S88TT14065 (Oxygen)
    • Publication Date:
      Date Created: 19790801 Date Completed: 19790925 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC372149
    • Accession Number:
      10.1172/JCI109492
    • Accession Number:
      457867