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Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.
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- Author(s): Guenou, Hind; Nissan, Xavier; Larcher, Fernando; Feteira, Jessica; Lemaitre, Gilles; Saidani, Manoubia; Del Rio, Marcela; Barrault, Christine C.; Bernard, François-Xavier; Peschanski, Marc; Baldeschi, Christine; Waksman, Gilles
- Source:
Lancet. 11/21/2009, Vol. 374 Issue 9703, p1745-1753. 9p. 3 Diagrams, 4 Graphs.
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- Abstract:
The article focuses on a study which investigated the possibility of using keratinocyte progeny of human embryonic stem cells (hESC) to create a temporary skin substitute for patients who are in line for autologous grafts. The study examined the capability of hESC to construct pluristratified epidermis. It utilized hESC from cell lines H9 and SA01, which were seeded in triplicate in fibroblast feeder cells for 40 days. The hESC created a homogenous cell population with the phenotypic characteristics of basal keratinocytes. Study authors concluded that hESC can be used to generate temporary skin substitutes for patients awaiting autologous grafts.
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