Role of 1,25-dihydroxyvitamin D3 in maintaining serum phosphorus and curing rickets.

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  • Author(s): Tanaka Y; Deluca HF
  • Source:
    Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1974 Apr; Vol. 71 (4), pp. 1040-4.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : National Academy of Sciences
    • Subject Terms:
      Hydroxycholecalciferols/*therapeutic use ; Phosphorus/*blood ; Rickets/*drug therapy; Animals ; Biological Transport/drug effects ; Calcification, Physiologic/drug effects ; Calcium/blood ; Calcium/metabolism ; Dihydroxycholecalciferols/administration & dosage ; Dihydroxycholecalciferols/pharmacology ; Dihydroxycholecalciferols/therapeutic use ; Dose-Response Relationship, Drug ; Hydroxycholecalciferols/pharmacology ; Injections, Intraperitoneal ; Injections, Intravenous ; Intestinal Mucosa/metabolism ; Male ; Phosphorus/metabolism ; Rats ; Rickets/blood ; Stimulation, Chemical
    • Abstract:
      The intravenous injection of a single dose of 650 pmoles of 1,25-dihydroxyvitamin D(3) to rats fed a vitamin D-deficient, low-phosphorus diet caused an elevation of serum phosphorus within 5 hours which reached a maximum in about 10-12 hours. This elevated serum phosphorus returned to deficiency levels 2-3 days later. On the other hand, a single injection of 650 pmoles of 25-hydroxyvitamin D(3) produced a significant rise at 12 hours, reached a maximum in 24-36 hours, and was maintained for at least 7 days. The single dose of 1,25-dihydroxyvitamin D(3) supported little calcification of bone, whereas the 25-hydroxyvitamin D(3) produced marked calcification. Six-hundred and fifty pmoles of 24,25-dihydroxyvitamin D(3) increased serum phosphorus only slightly and induced no calcification. When 1,25-dihydroxyvitamin D(3) was given each day, a sustained increase in serum phosphorus and marked bone calcification resulted. In contrast to the serum phosphorus responses, intestinal calcium transport remained high 5 days after administration of a single dose of 1,25-dihydroxyvitamin D(3). Serum calcium was not changed appreciably by any of the metabolites. Thyroparathyroidectomized rats or rats fed a diet extremely deficient in phosphate still exhibited a marked elevation of serum phosphorus in response to 1,25-dihydroxyvitamin D(3). The effect of 1,25-dihydroxyvitamin D(3) on serum phosphorus was greatly reduced in nephrectomized rats, suggesting that the serum phosphorus response to 1,25-dihydroxyvitamin D(3) may arise from an enhancement of phosphate reabsorption in the renal tubules. It is suggested that 1,25-dihydroxyvitamin D(3) cures rickets in rats by increasing the concentration of serum phosphorus rather than by increasing serum calcium concentration and calcium absorption.
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    • Accession Number:
      0 (Dihydroxycholecalciferols)
      0 (Hydroxycholecalciferols)
      27YLU75U4W (Phosphorus)
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 19740401 Date Completed: 19740731 Latest Revision: 20190501
    • Publication Date:
      20231215
    • Accession Number:
      PMC388157
    • Accession Number:
      10.1073/pnas.71.4.1040
    • Accession Number:
      4524612