KINETIKA EKSTRAKCIJE SISTEMA Macleaya cordata -- ETANOL. (Serbian).

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    • Subject Terms:
      EXTRACTION (Chemistry); ALCOHOLS (Chemical class); PLANT extracts; PLANT cells & tissues; MASS transfer; SOLVENTS
    • Abstract:
      Extraction kinetics of system Macleaya cordata (herba) -- ethanol was investigated. The values of coefficients of rapid extraction (b) and slow extraction (k) increase with increasing of grinding degree of plant material. The value b increases with increasing of temperature from room temperature of 30°C to temperature of 50°C, due to increasing investigated substances solubility in used solvent. Also, coefficient of rapid extraction increases with increasing of drug -- solvent ratio, as a result of increasing the available volumes of solvent and mass transfer force from surface of plant particles to the fluid extract. Further more, the value b depends on the applied solvent. The value k increases because the distance from interior of particles to particles surfaces is shorter. Contrary, the value of internal diffusion coefficient (Du) declines. With increasing of grinding degree of drug significantly destruction of the plant tissue structure was achieved, what means that turbulent mass transfer has dominant role for extraction. Maceration with constantly mixing by 80% (w/w) ethanol as solvent has the highest yield of sanguinarine (0.52%) and chelerythrine (0.80%) extraction after 120 min, using with drug --solvent ratio of 1:20 (w/v). [ABSTRACT FROM AUTHOR]
    • Abstract:
      Ispitivanjem kinetike ekstrakcije sistema: Macleaya cordata (herba) -- etanol, nađeno je da sa porastom stepena usitnjenosti biljnog materijala raste vrednost koeficijenta brze (b) i spore (k) ekstrakcije. Vrednost b raste sa povećanjem temperature, od sobne (30°C) do 50°C, zbog povećanja rastvorljivosti ispitivanih supstanci u rastvaraču. Takođe, koeficijent brze ekstrakcije se povećava i sa povećanjem odnosa droga -- rastvarač, kao rezultat povećanja dostupne zapremine rastvarača i pogonske sile prenosa mase od površine čestica biljnog materijala u masu tečnog ekstrakta. Nadalje, nađeno je da vrednosti b zavise i od primenjenog rastvarača. Povećanje vrednosti k nastaje zbog kraćeg rastojanja koje treba da pređu supstance difuzijom od unutrašnjosti čestica do njihove spoljašnje površine. Nasuprot ovome, vrednost koeficijenta unutrašnje difuzije (Du) opada. Sa porastom stepena usitnjenosti droge postiže se znatno razaranje strukture biljnog tkiva tako da pri ekstrakciji dominantnu ulogu ima turbulentni prenos mase. Primenom postupka maceracije uz stalno mešanje i etanola koncentracije 80% (m/m) kao rastvarača, ostvaren je najveći prinos ekstrakcije sangvinarina (0,52%) i heleritrina (0,80%) za 120 minuta, pri odnosu droga -- rastvarač 1:20 (m/v). [ABSTRACT FROM AUTHOR]