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Randomized trial of oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of spontaneous preterm labor in Taiwanese women.
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- Author(s): Lin, Chia-Hui; Lin, Shin-Yu; Shyu, Ming-Kwang; Chen, Shee-Uan; Lee, Chien-Nan
- Source:
Journal of the Formosan Medical Association; Jun2009, Vol. 108 Issue 6, p493-501, 9p- Subject Terms:
CLINICAL trials; OXYTOCIN; CHEMICAL inhibitors; ADRENERGIC beta agonists; PREMATURE labor; UTERINE contraction; DRUG efficacy; INTRAVENOUS therapy; TOCOLYTIC agents; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; PITUITARY hormones; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; THERAPEUTICS - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background/purpose: Management of preterm labor involves the use of tocolytic drugs to inhibit preterm uterine contractions. This study compared the efficacy and safety of intravenous administration of atosiban and ritodrine in the treatment of spontaneous preterm labor.Methods: A randomized study was conducted in pregnant women of Chinese origin in Taiwan with threatened preterm delivery. Patients were randomized to receive either atosiban (n = 23) or ritodrine (n = 22). Tocolytic efficacy of the drug was assessed as the proportion of women who did not deliver and did not need alternative tocolytic treatment at 7 days after therapy initiation. Safety of the drugs was assessed as the number of adverse events or neonatal morbidity.Results: The number of women who did not deliver and did not require alternative tocolytic therapy at 7 days was similar between the atosiban and ritodrine groups. There were no serious adverse events, but maternal cardiovascular adverse events, particularly tachycardia, occurred significantly more in women treated with ritodrine (0% atosiban vs. 18.18% ritodrine, p < 0.05). There was no difference in neonatal or infant outcome between the two drugs.Conclusion: The present study showed similar effectiveness between atosiban and ritodrine, while tachycardia occurred more frequently in women treated with ritodrine. These results indicate that atosiban is an effective tocolytic drug without the conventional cardiovascular side effects often seen with beta-agonist treatment. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Journal of the Formosan Medical Association is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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