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Effect of sex hormones on hypoprothrombinemia induced by N-methyltetrazolethiol in rats.
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- Additional Information
- Source:
Publisher: Pergamon Press Country of Publication: United States NLM ID: 0326377 Publication Model: Print Cited Medium: Print ISSN: 0049-3848 (Print) Linking ISSN: 00493848 NLM ISO Abbreviation: Thromb Res Subsets: MEDLINE
- Publication Information:
Original Publication: Elmsford, N. Y., Pergamon Press.
- Subject Terms:
- Abstract:
N-Methyltetrazolethiol (NMTT) increased prothrombin time (PT) and decreased plasma factor VII and prothrombin levels only in vitamin K-deficient male rats. In female rats identical treatment with NMTT did not produce hypoprothrombinemia. Conventional and germ-free rats displayed no significant difference in the manifestation of hypoprothrombinemia, but the increase of PT in NMTT-treated vitamin K-deficient rats was greater in the germ-free males. Estradiol administration or castration of male rats retarded manifestation of vitamin K deficient syndromes such as increases of PT and activated partial thromboplastin time (APTT), decreases of plasma factor VII and prothrombin levels, and increases of plasma and liver descarboxyprothrombin (PIVKA) levels, and testosterone injection to the castrated rats restored these changes. In female rats testosterone treatment or castration enhanced the manifestation of hypoprothrombinemia and estradiol treatment to the castrated females retarded it. Gamma-glutamyl-carboxylase activity was increased by vitamin K-deficiency but not inhibited by testosterone or NMTT. These data suggest that estrogen protects the rat against manifestation of hypoprothrombinemia even with NMTT treatment, while androgen enhances vitamin K deficiency, and supplementation of vitamin K prevents its deficiency in NMTT-treated rats.
- Accession Number:
0 (Azoles)
0 (Gonadal Steroid Hormones)
0 (Tetrazoles)
13183-79-4 (1-N-methyl-5-thiotetrazole)
3XMK78S47O (Testosterone)
4TI98Z838E (Estradiol)
9001-25-6 (Factor VII)
9001-26-7 (Prothrombin)
- Publication Date:
Date Created: 19850915 Date Completed: 19860129 Latest Revision: 20190727
- Publication Date:
20221213
- Accession Number:
10.1016/0049-3848(85)90258-0
- Accession Number:
4082108
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