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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Psychosis and autism: magnetic resonance imaging study of brain anatomy.
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- Author(s): Toal, Fiona; Bloeman, Oswald J. N.; Deeley, Quinton; Tunstall, Nigel; Daly, Eileen M.; Page, Lisa; Brammer, Michael J.; Murphy, Kieran C.; Murphy, Declan G. M.; Bloemen, Oswald J N (AUTHOR)
- Source:
British Journal of Psychiatry. May2009, Vol. 194 Issue 5, p418-425. 8p. 3 Diagrams, 5 Charts. - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: Autism-spectrum disorder is increasingly recognised, with recent studies estimating that 1% of children in South London are affected. However, the biology of comorbid mental health problems in people with autism-spectrum disorder is poorly understood.Aims: To investigate the brain anatomy of people with autism-spectrum disorder with and without psychosis.Method: We used in vivo magnetic resonance imaging and compared 30 adults with autism-spectrum disorder (14 with a history psychosis) and 16 healthy controls.Results: Compared with controls both autism-spectrum disorder groups had significantly less grey matter bilaterally in the temporal lobes and the cerebellum. In contrast, they had increased grey matter in striatal regions. However, those with psychosis also had a significant reduction in grey matter content of frontal and occipital regions. Contrary to our expectation, within autism-spectrum disorder, comparisons revealed that psychosis was associated with a reduction in grey matter of the right insular cortex and bilaterally in the cerebellum extending into the fusiform gyrus and the lingual gyrus.Conclusions: The presence of neurodevelopmental abnormalities normally associated with autism-spectrum disorder might represent an alternative 'entry-point' into a final common pathway of psychosis. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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