Comprehension of acoustically degraded emotional prosody in Alzheimer's disease and primary progressive aphasia.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Alzheimer Disease*/psychology ; Alzheimer Disease*/physiopathology ; Aphasia, Primary Progressive*/psychology ; Emotions*/physiology ; Comprehension*/physiology ; Speech Perception*/physiology; Humans ; Male ; Female ; Aged ; Middle Aged ; Aged, 80 and over ; Case-Control Studies
    • Abstract:
      Previous research suggests that emotional prosody perception is impaired in neurodegenerative diseases like Alzheimer's disease (AD) and primary progressive aphasia (PPA). However, no previous research has investigated emotional prosody perception in these diseases under non-ideal listening conditions. We recruited 18 patients with AD, and 31 with PPA (nine logopenic (lvPPA); 11 nonfluent/agrammatic (nfvPPA) and 11 semantic (svPPA)), together with 24 healthy age-matched individuals. Participants listened to speech stimuli conveying three emotions in clear and noise-vocoded forms and had to identify the emotion being conveyed. We then conducted correlation analyses between task performance and measures of socio-emotional functioning. All patient groups showed significant impairments in identifying clear emotional prosody compared to healthy individuals. These deficits were exacerbated under noise-vocoded conditions, with all patient groups performing significantly worse than healthy individuals and patients with lvPPA performing significantly worse than those with svPPA. Significant correlations with social cognition measures were observed more consistently for noise-vocoded than clear emotional prosody comprehension. These findings open a window on a dimension of real-world emotional communication that has often been overlooked in dementia, with particular relevance to social cognition, and begin to suggest a novel candidate paradigm for investigating and quantifying this systematically.
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval: All participants gave informed consent to take part in the study, in accordance with Declaration of Helsinki guidelines. Ethical approval was granted by the University College London-National Hospital for Neurology and Neurosurgery Joint Research Ethics Committees.
      (© 2024. The Author(s).)
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    • Grant Information:
      Frontotemporal Dementia Research Studentship in Memory of David Blechner National Brain Appeal; Clinical Research Training Fellowship Association of British Neurologists; 102129/B/13/z United Kingdom WT_ Wellcome Trust; 205167/Z/16/Z United Kingdom WT_ Wellcome Trust; PhD Studentship Brain Research UK; Clinical Research Fellowship Leonard Wolfson Experimental Neurology Centre; NIHR302240 National Institute for Health and Care Research; NIHR204280 National Institute for Health and Care Research; G105 Royal National Institute for Deaf People; AS-PG-16-007 United Kingdom ALZS_ Alzheimer's Society; 627 United Kingdom ALZS_ Alzheimer's Society; PA23 Dunhill Medical Trust
    • Contributed Indexing:
      Keywords: Alzheimer’s disease; Degraded speech; Dementia; Emotional prosody; Frontotemporal dementia; Noise-vocoding; Primary progressive aphasia; Social cognition
    • Publication Date:
      Date Created: 20241229 Date Completed: 20241229 Latest Revision: 20250104
    • Publication Date:
      20250104
    • Accession Number:
      PMC11682080
    • Accession Number:
      10.1038/s41598-024-82694-z
    • Accession Number:
      39732859