Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2020- : [Hoboken, NJ] : Wiley
      Original Publication: Heidelberg : Springer-Verlag
    • Subject Terms:
    • Abstract:
      Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
      (© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)
    • Grant Information:
      2022YFC2704700 National Key Research and Development Program of China; 2018YFC1002900 National Key Research and Development Program of China; 82071656 National Natural Science Foundation of China; 21Y11907500 Shanghai Municipal Science and Technology Commission; 23DZ2303400 Shanghai Municipal Science and Technology Commission
    • Publication Date:
      Date Created: 20241220 Date Completed: 20241220 Latest Revision: 20241220
    • Publication Date:
      20241220
    • Accession Number:
      10.1002/ctm2.70130
    • Accession Number:
      39702938