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Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.
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- Additional Information
- Source:
Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE
- Publication Information:
Publication: 2020- : [Hoboken, NJ] : Wiley
Original Publication: Heidelberg : Springer-Verlag
- Subject Terms:
- Abstract:
Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
(© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)
- Grant Information:
2022YFC2704700 National Key Research and Development Program of China; 2018YFC1002900 National Key Research and Development Program of China; 82071656 National Natural Science Foundation of China; 21Y11907500 Shanghai Municipal Science and Technology Commission; 23DZ2303400 Shanghai Municipal Science and Technology Commission
- Publication Date:
Date Created: 20241220 Date Completed: 20241220 Latest Revision: 20241220
- Publication Date:
20241220
- Accession Number:
10.1002/ctm2.70130
- Accession Number:
39702938
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