Management and toxicological analysis of ocular hypertension after EyeCee ^® ONE intraocular lens implantation: a case series.

Publisher: BioMed Central Country of Publication: England NLM ID: 100967802 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2415 (Electronic) Linking ISSN: 14712415 NLM ISO Abbreviation: BMC Ophthalmol Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Ocular Hypertension*/etiology ; Intraocular Pressure*/physiology ; Lens Implantation, Intraocular*/adverse effects ; Phacoemulsification*/adverse effects ; Lenses, Intraocular*/adverse effects; Humans ; Aged ; Male ; Female ; Aqueous Humor/metabolism ; Middle Aged ; Aged, 80 and over ; Silicon ; Prosthesis Failure ; Postoperative Complications

Background: The EyeCee ^® ONE intraocular lens (Nidek, Gamagori, Japan) has been withdrawn from the market due to a high number of reports of severe ocular hypertension (OHT) following phacoemulsification with implantation of this intraocular lens (IOL). In this case series, we report the results of a toxicological analysis and the surgical management of five patients with severe OHT following the implantation of defective EyeCee ^® ONE IOLs during cataract surgery.
Cases Presentation: Five patients developed early, severe OHT refractory to maximal medical therapy following uneventful phacoemulsification (PCE) cataract surgery with implantation of an EyeCee ^® ONE IOL from a defective lot. Glaucoma filtering surgeries were required to control intraocular pressure (IOP). Toxicological analyses were carried out on the aqueous humor of one patient. IOP levels were monitored during postoperative follow-up, but three patients required postoperative adjustments (reintroduction of IOP-lowering therapy, goniopuncture or needling) in order to maintain IOP at satisfactory levels. Toxicological analysis revealed a high concentration of silicon in the aqueous humor of the patient from whom the sample was obtained.
Conclusions: These cases of OHT following cataract surgery with a defective IOL were of early onset severe, all requiring filtering surgery. The exact mechanism of this OHT has not been determined, but we did find high concentrations of silicon in the aqueous humor of one of these patients. Patients who received EyeCee ^® ONE IOLs during the same period of time should have their IOP and optic nerve monitored to detect any potential OHT or glaucoma that might appear over time.
Competing Interests: Declarations. Ethical approval: The study was made in accordance with the principles of the Declaration of Helsinki. Consent for publication: Written informed consent was obtained from all patients for the publication of this case series, after an explanation of the study design and purpose by their treating physician. Patients’ confidentiality was ensured. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)

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Keywords: Glaucoma; Intraocular lens; Ocular hypertension; Phacoemulsification; Toxicology

Z4152N8IUI (Silicon)

Date Created: 20241219 Date Completed: 20241219 Latest Revision: 20241219

20241219

10.1186/s12886-024-03810-1

39696055