Dynamic interaction of antibiotic resistance between plant microbiome and organic fertilizers: sources, dissemination, and health risks.

Publisher: Springer Country of Publication: Germany NLM ID: 9012472 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-0972 (Electronic) Linking ISSN: 09593993 NLM ISO Abbreviation: World J Microbiol Biotechnol Subsets: MEDLINE

Publication: 2005- : Berlin : Springer
Original Publication: Oxford, OX, UK : Published by Rapid Communications of Oxford Ltd in association with UNESCO and in collaboration with the International Union of Microbiological Societies, c1990-

Anti-Bacterial Agents*/pharmacology ; Bacteria*/drug effects ; Bacteria*/genetics ; Bacteria*/classification ; Fertilizers*/analysis ; Manure*/microbiology ; Microbiota*/drug effects ; Plants*/microbiology ; Soil Microbiology*; Animals ; Humans ; Agriculture/methods ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Gene Transfer, Horizontal ; Sewage/microbiology ; Soil/chemistry ; Wastewater/chemistry ; Wastewater/microbiology

Antibiotic resistance is a global health problem driven by the irrational use of antibiotics in different areas (such as agriculture, animal farming, and human healthcare). Sub-lethal concentrations of antibiotic residues impose selective pressure on environmental, plant-associated, and human microbiome leading to the emergence of antibiotic-resistant bacteria (ARB). This review summarizes all sources of antibiotic resistance in agricultural soils (including manure, sewage sludge, wastewater, hospitals/pharmaceutical industry, and bioinoculants). The factors (such as the physicochemical properties of soil, root exudates, concentration of antibiotic exposure, and heavy metals) that facilitate the transmission of resistance in plant microbiomes are discussed. Potential solutions for effective measures and control of antibiotic resistance in the environment are also hypothesized. Manure exhibits the highest antibiotics load, followed by hospital and municipal WW. Chlortetracycline, tetracycline, and sulfadiazine have the highest concentrations in the manure. Antibiotic resistance from organic fertilizers is transmitted to the plant microbiome via horizontal gene transfer (HGT). Plant microbiomes serve as transmission routes of ARB and ARGS to humans. The ingestion of ARB leads to human health risks (such as ineffectiveness of medication, increased morbidity, and mortality).
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)

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lzujbky-2024-ey12 Fundamental Research Funds for the Central Universities

Keywords: Agriculture; Antibiotics; Bacteria; Bioinoculants; Microbiome; Resistance

0 (Anti-Bacterial Agents)
0 (Fertilizers)
0 (Manure)
0 (Sewage)
0 (Soil)
0 (Wastewater)

Date Created: 20241217 Date Completed: 20241217 Latest Revision: 20241220

20241221

10.1007/s11274-024-04214-5

39690351