YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Keratinocytes*/metabolism ; Keratinocytes*/cytology ; Signal Transduction* ; Transcription Factors*/metabolism ; YAP-Signaling Proteins*/metabolism ; Adaptor Proteins, Signal Transducing*/metabolism; Humans ; Animals ; Cell Differentiation ; Transcriptional Coactivator with PDZ-Binding Motif Proteins/metabolism ; Epidermis/metabolism ; Epidermal Cells/metabolism ; Trans-Activators/metabolism
    • Abstract:
      The paralogues Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) control cell proliferation and cell fate determination from embryogenesis to ageing. In the skin epidermis, these proteins are involved in both homeostatic cell renewal and injury-induced regeneration and also drive carcinogenesis and other pathologies. YAP and TAZ are usually considered downstream of the Hippo pathway. However, they are the central integrating link for the signalling microenvironment since they are involved in the interplay with signalling cascades induced by growth factors, cytokines, and physical parameters of the extracellular matrix. In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling molecules at the plasma membrane, cytoplasmic, and nuclear levels; and how YAP/TAZ ultimately controls transcription programmes, defining epidermal cell fate.
    • Grant Information:
      075-15-2024-539 Ministry of Science and Higher Education of the Russian Federation
    • Contributed Indexing:
      Keywords: Hippo; TAZ; YAP; epidermis; keratinocytes; signalling; skin; transcription
    • Accession Number:
      0 (Transcription Factors)
      0 (YAP-Signaling Proteins)
      0 (Adaptor Proteins, Signal Transducing)
      0 (Transcriptional Coactivator with PDZ-Binding Motif Proteins)
      0 (YAP1 protein, human)
      0 (WWTR1 protein, human)
      0 (Trans-Activators)
    • Publication Date:
      Date Created: 20241217 Date Completed: 20241217 Latest Revision: 20241218
    • Publication Date:
      20241219
    • Accession Number:
      10.3390/ijms252312903
    • Accession Number:
      39684613