Innovative Approaches to Fucoxanthin Delivery: Characterization and Bioavailability of Solid Lipid Nanoparticles with Eco-Friendly Ingredients and Enteric Coating.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Xanthophylls*/pharmacokinetics ; Xanthophylls*/chemistry ; Xanthophylls*/administration & dosage ; Nanoparticles*/chemistry ; Biological Availability* ; Rats, Sprague-Dawley* ; Lipids*/chemistry; Animals ; Rats ; Humans ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Male ; Particle Size ; Drug Delivery Systems/methods ; Liposomes
    • Abstract:
      Fucoxanthin (FN), a carotenoid derived from brown seaweed and algae, offers significant health benefits. However, its unique structure leads to challenges in stability and bioavailability. To overcome these issues, we successfully encapsulated fucoxanthin in solid lipid nanoparticles (SLNs) utilizing health-safe materials, achieving remarkable results. SLNs exhibited a nanoscale size of 248.98 ± 4.0 nm, along with an impressive encapsulation efficiency of 98.30% ± 0.26% and a loading capacity of 5.48% ± 0.82% in lipid. The polydispersity index (PDI) was measured at 0.161 ± 0.03, indicating a narrow size distribution, while the high negative zeta potential of -32.93 ± 1.2 mV suggests excellent stability. Pharmacokinetic studies conducted in Sprague-Dawley rats revealed an exceptional oral bioavailability of 2723.16% compared to fucoxanthin crystals, likely attributed to the enhanced stability and improved cellular uptake of the SLNs. To further improve bioavailability, we creatively applied enteric coatings to the freeze-dried SLNs, effectively protecting fucoxanthin from gastric degradation, which is supported by in vitro digestion results. These findings underscore the potential of SLNs as a superior delivery system for fucoxanthin, significantly enhancing its therapeutic efficacy and broadening its application in the food and pharmaceutical industries.
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    • Contributed Indexing:
      Keywords: bioavailability; encapsulation; enteric coating; fucoxanthin; nano drug delivery; solid lipid nanoparticle (SLN)
    • Accession Number:
      06O0TC0VSM (fucoxanthin)
      0 (Xanthophylls)
      0 (Lipids)
      0 (Drug Carriers)
      0 (Lipid Nanoparticles)
      0 (Liposomes)
    • Publication Date:
      Date Created: 20241217 Date Completed: 20241217 Latest Revision: 20250104
    • Publication Date:
      20250104
    • Accession Number:
      PMC11641657
    • Accession Number:
      10.3390/ijms252312825
    • Accession Number:
      39684536