A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm in Drosophila .

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  • Author(s): Peterson SK;Peterson SK; Ahmad ST; Ahmad ST
  • Source:
    International journal of molecular sciences [Int J Mol Sci] 2024 Nov 24; Vol. 25 (23). Date of Electronic Publication: 2024 Nov 24.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • Subject Terms:
      Circadian Rhythm*/drug effects ; Circadian Rhythm*/genetics ; Ethanol*/pharmacology ; Drosophila Proteins*/genetics ; Drosophila Proteins*/metabolism ; Drosophila melanogaster*/genetics ; Drosophila melanogaster*/drug effects ; Drosophila melanogaster*/physiology ; Drug Tolerance*/genetics; Animals ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Neurons/metabolism ; Neurons/drug effects
    • Abstract:
      Alcohol consumption and addiction remain global health concerns, with significant loss of productivity, morbidity, and mortality. Drosophila melanogaster , a widely used model organism, offers valuable insights into the genetic and neuronal mechanisms underlying ethanol-induced behaviors (EIBs) such as sedation, recovery, and tolerance. This narrative review focuses on studies in the Drosophila model system suggesting an association between circadian rhythm genes as modulators of ethanol tolerance. Mutations in these genes disrupt both the circadian cycle and tolerance, underscoring the interplay between circadian rhythm and ethanol processing although the exact mechanisms remain largely unknown. Additionally, genes involved in stress response, gene expression regulation, neurotransmission, and synaptic activity were implicated in ethanol tolerance modulation. At the neuronal level, recent studies have highlighted the involvement of corazonin (CRZ) and neuropeptide F (NPF) neurons in modulating EIBs. Understanding the temporal dynamics of tolerance development is crucial for describing the molecular basis of ethanol tolerance. Ultimately, insights gained from Drosophila studies hold promise for elucidating the neurobiological underpinnings of alcohol use disorders and addiction, contributing to more effective interventions and treatments.
    • Grant Information:
      P20GM0103423 National Institute of General Medical Sciences of the National Institutes of Health
    • Contributed Indexing:
      Keywords: Drosophila; circadian rhythm; ethanol-induced behaviors; genetics; tolerance
    • Accession Number:
      3K9958V90M (Ethanol)
      0 (Drosophila Proteins)
      0 (Neuropeptides)
      0 (Crz protein, Drosophila)
      0 (neuropeptide F, Drosophila)
    • Publication Date:
      Date Created: 20241217 Date Completed: 20241217 Latest Revision: 20241217
    • Publication Date:
      20241217
    • Accession Number:
      10.3390/ijms252312605
    • Accession Number:
      39684317