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Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany.
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- Author(s): Fleckenstein JM;Fleckenstein JM; Najjar SM; Najjar SM; Zimmermann W; Zimmermann W; Hauck CR; Hauck CR; Nguyen Q; Nguyen Q; Mejias-Luque R; Mejias-Luque R; Bhattacharyya A; Bhattacharyya A; McCarthy AJ; McCarthy AJ; Sarkar A; Sarkar A; Kujawski M; Kujawski M; Konieva A; Konieva A; Elyateem F; Elyateem F; Kube-Golovin I; Kube-Golovin I; Wennemuth G; Wennemuth G; Kammerer R; Kammerer R; Skubitz KM; Skubitz KM; Shively JE; Shively JE; Dery KJ; Dery KJ; Dveksler G; Dveksler G; Götz L; Götz L; Kleefeldt F; Kleefeldt F; Ergün S; Ergün S
- Source:
European journal of clinical investigation [Eur J Clin Invest] 2024 Dec; Vol. 54 Suppl 2, pp. e14355.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: In Process; MEDLINE
- Publication Information: Publication: Oxford : Wiley
Original Publication: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation. - References: Zhuo Y, Yang JY, Moremen KW, Prestegard JH. Glycosylation alters dimerization properties of a cell‐surface signaling protein, Carcinoembryonic Antigen‐related Cell Adhesion Molecule 1 (CEACAM1). J Biol Chem. 2016;291(38):20085‐20095.
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Muenzner P, Naumann M, Meyer TF, Gray‐Owen SD. Pathogenic Neisseria trigger expression of their carcinoembryonic antigen‐related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear factor‐kappaB. J Biol Chem. 2001;276(26):24331‐24340.
Koniger V, Holsten L, Harrison U, et al. Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat Microbiol. 2016;2:16188.
Tchoupa AK, Lichtenegger S, Reidl J, Hauck CR. Outer membrane protein P1 is the CEACAM‐binding adhesin of Haemophilus influenzae. Mol Microbiol. 2015;98(3):440‐455.
Hill DJ, Virji M. A novel cell‐binding mechanism of Moraxella catarrhalis ubiquitous surface protein UspA: specific targeting of the N‐domain of carcinoembryonic antigen‐related cell adhesion molecules by UspA1. Mol Microbiol. 2003;48(1):117‐129.
Galaski J, Shhadeh A, Umana A, et al. Fusobacterium nucleatum CbpF mediates inhibition of T cell function through CEACAM1 activation. Front Cell Infect Microbiol. 2021;11:692544.
Brewer ML, Dymock D, Brady RL, Singer BB, Virji M, Hill DJ. Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF. J Oral Microbiol. 2019;11(1):1565043.
Klaile E, Muller MM, Schafer MR, et al. Binding of Candida albicans to human CEACAM1 and CEACAM6 modulates the inflammatory response of intestinal epithelial cells. MBio. 2017;8(2):e02142‐16.
Zimmermann W. Evolution: decoy receptors as unique weapons to fight pathogens. Curr Biol. 2019;29(4):R128‐R130.
Sheikh A, Tumala B, Vickers TJ, et al. Enterotoxigenic Escherichia coli heat‐labile toxin drives enteropathic changes in small intestinal epithelia. Nat Commun. 2022;13(1):6886.
Sheikh A, Ganguli D, Vickers TJ, et al. Host‐derived CEACAM‐laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization. Proc Natl Acad Sci USA. 2024;121(38):e2410679121.
Sadarangani M, Pollard AJ, Gray‐Owen SD. Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria. FEMS Microbiol Rev. 2011;35(3):498‐514.
Conners R, Hill DJ, Borodina E, et al. The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled‐coil. EMBO J. 2008;27(12):1779‐1789.
Javaheri A, Kruse T, Moonens K, et al. Helicobacter pylori adhesin HopQ engages in a virulence‐enhancing interaction with human CEACAMs. Nat Microbiol. 2016;2:16189.
Chen YC, Malfertheiner P, Yu HT, et al. Global prevalence of helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022. Gastroenterology. 2024;166(4):605‐619.
Taxauer K, Hamway Y, Ralser A, et al. Engagement of CEACAM1 by Helicobacterpylori HopQ is important for the activation of non‐canonical NF‐kappaB in gastric epithelial cells. Microorganisms. 2021;9(8):1748.
Poirah ICD, Dixit P, Samal S, et al. Association between CEACAMs and hypoxia defines gastric cancer progression. Paper presented at: proceedings of the American Association for Cancer Research annual meeting. Vol 81; 2021:1988.
Chean J, Chen CJ, Gugiu G, et al. Human CEACAM1‐LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. J Biol Chem. 2021;297(5):101311.
Zaidi S, Asalla S, Muturi HT, et al. Loss of CEACAM1 in hepatocytes causes hepatic fibrosis. Eur J Clin Investig. 2024;54(7):e14177.
Najjar SM, Caprio S, Gastaldelli A. Insulin clearance in health and disease. Annu Rev Physiol. 2023;85:363‐381.
Poy MN, Yang Y, Rezaei K, et al. CEACAM1 regulates insulin clearance in liver. Nat Genet. 2002;30(3):270‐276.
Helal RA, Russo L, Ghadieh HE, et al. Regulation of hepatic fibrosis by carcinoembryonic antigen‐related cell adhesion molecule 1. Metabolism. 2021;121:154801.
Muturi HT, Ghadieh HE, Abdolahipour R, et al. Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. Metabolism. 2023;144:155562.
Muturi HT, Ghadieh HE, Asalla S, et al. Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation. Mol Metab. 2024;88:102010.
Nakamura K, Kageyama S, Kaldas FM, et al. Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury. J Clin Invest. 2020;130(5):2689‐2704.
Dery KJ, Kojima H, Kageyama S, et al. Alternative splicing of CEACAM1 by hypoxia‐inducible factor‐1α enhances tolerance to hepatic ischemia in mice and humans. Sci Transl Med. 2023;15(707):eadf2059.
Hirao H, Kojima H, Dery KJ, et al. Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation. J Clin Invest. 2023;133(3):e162940.
Kojima H, Kadono K, Hirao H, et al. T cell CEACAM1‐TIM‐3 crosstalk alleviates liver transplant injury in mice and humans. Gastroenterology. 2023;165(5):1233‐1248.
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Huang YH, Zhu C, Kondo Y, et al. CEACAM1 regulates TIM‐3‐mediated tolerance and exhaustion. Nature. 2015;517(7534):386‐390.
Hirao H, Kojima H, Dery KJ, et al. Neutrophil CEACAM1 determines the susceptibility to NETosis by regulating S1PR2/S1PR3 Axis in liver transplantation: from bench‐to‐bedside. J Clin Invest. 2023;133:e162940.
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Rattila S, Dunk CEE, Im M, et al. Interaction of pregnancy‐specific glycoprotein 1 with integrin Alpha5beta1 is a modulator of extravillous trophoblast functions. Cells. 2019;8(11):1369.
Ghavampour S, Kleefeldt F, Bommel H, et al. Endothelial barrier function is differentially regulated by CEACAM1‐mediated signaling. FASEB J. 2018;32(10):5612‐5625.
Kleefeldt F, Bommel H, Broede B, et al. Aging‐related carcinoembryonic antigen‐related cell adhesion molecule 1 signaling promotes vascular dysfunction. Aging Cell. 2019;18(6):e13025.
Kleefeldt F, Rueckschloss U, Ergun S. CEACAM1 promotes vascular aging processes. Aging (Albany NY). 2020;12(4):3121‐3123. - Grant Information: P30 DK052574 United States DK NIDDK NIH HHS; R01-DK054254 United States DK NIDDK NIH HHS; R01-MD012579 United States DK NIDDK NIH HHS; DFG Si 1558/6-1 Deutsche Forschungsgemeinschaft; R01 AI089894 United States AI NIAID NIH HHS; R01 AI170949 United States AI NIAID NIH HHS; 5I01BX001469-05 U.S. Department of Veterans Affairs; HORIZON-MSCA-2021-SE-01-01 European Commission; Osteopathic Heritage Foundation
- Contributed Indexing: Keywords: CEACAM; atherogenesis; cancer; immunity; metabolism; reproduction
- Publication Date: Date Created: 20241215 Latest Revision: 20241215
- Publication Date: 20241216
- Accession Number: 10.1111/eci.14355
- Accession Number: 39674873
- Source:
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