[Research progress on the cognitive deficit of Down syndrome patients].

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Shi W;Shi W; Liao S
  • Source:
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2024 Dec 10; Vol. 41 (12), pp. 1503-1507.
  • Publication Type:
    Journal Article; Review; English Abstract
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Sichuan University Country of Publication: China NLM ID: 9425197 Publication Model: Print Cited Medium: Print ISSN: 1003-9406 (Print) Linking ISSN: 10039406 NLM ISO Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: <2004->: Chengdu, Sichuan, P.R. China : Sichuan University
      Original Publication: Chengdu : Hua xi yi ke da xue,
    • Subject Terms:
      Down Syndrome*/genetics ; Down Syndrome*/complications ; Down Syndrome*/psychology ; Protein-Tyrosine Kinases*/genetics ; Dyrk Kinases* ; Protein Serine-Threonine Kinases*/genetics; Humans ; Cognition Disorders/genetics ; Cognition Disorders/etiology
    • Abstract:
      As the most common chromosomal disorder compatible to life, Down syndrome (DS) is caused by an extra copy of chromosome 21. Almost all DS patients have cognitive dysfunction. Therefore, it is important to study the underlying pathogenetic mechanism to elucidate its molecular basis. This article has provided a review for the molecular mechanisms of NRIP1 and DYRK1A genes, which have been closely associated with the cognitive dysfunctions of DS patients. It has also summarized the research progress on the mechanism of DS and development of new therapeutic strategies based on such studies, with an aim to provide insights into the prevention and treatment for the cognitive dysfunctions in DS patients.
    • Accession Number:
      EC 2.7.10.1 (Protein-Tyrosine Kinases)
      EC 2.7.1.- (Dyrk Kinases)
      EC 2.7.11.1 (Protein Serine-Threonine Kinases)
    • Publication Date:
      Date Created: 20241209 Date Completed: 20241209 Latest Revision: 20241209
    • Publication Date:
      20241210
    • Accession Number:
      10.3760/cma.j.cn511374-20240624-00350
    • Accession Number:
      39653359