Dose independent pharmacokinetics of mexiletine in healthy volunteers.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Print ISSN: 0306-5251 (Print) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: London, Macmillan Journals Ltd.
    • Subject Terms:
      Mexiletine/*blood ; Propylamines/*blood; Administration, Oral ; Blood Pressure/drug effects ; Dizziness/chemically induced ; Dose-Response Relationship, Drug ; Half-Life ; Heart Rate/drug effects ; Humans ; Kinetics ; Male ; Mexiletine/administration & dosage ; Mexiletine/adverse effects ; Nausea/chemically induced ; Vision Disorders/chemically induced
    • Abstract:
      In 12 healthy volunteers who received orally 100, 200, 300, 400 and 600 mg mexiletine at weekly intervals, the maximum plasma concentration of mexiletine and AUC increased linearly with the dose of mexiletine. Between doses there were no significant differences in the values for clearance and volume of distribution of mexiletine but there were for plasma elimination half-life. These results indicate that the kinetics of mexiletine are linear.
    • References:
      Lancet. 1975 Aug 9;2(7928):247-8. (PMID: 49797)
      Postgrad Med J. 1977;53 Suppl 1:50-5. (PMID: 876954)
      Eur J Clin Pharmacol. 1984;26(1):129-31. (PMID: 6714286)
      Br J Clin Pharmacol. 1978 Aug;6(2):103-8. (PMID: 678385)
      Drugs. 1979 Mar;17(3):161-81. (PMID: 378646)
      Postgrad Med J. 1977;53 Suppl 1:60-8. (PMID: 17857)
    • Accession Number:
      0 (Propylamines)
      1U511HHV4Z (Mexiletine)
    • Publication Date:
      Date Created: 19860301 Date Completed: 19860528 Latest Revision: 20190511
    • Publication Date:
      20221213
    • Accession Number:
      PMC1400855
    • Accession Number:
      10.1111/j.1365-2125.1986.tb05196.x
    • Accession Number:
      3964531