Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes.

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  • Additional Information
    • Source:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
    • Subject Terms:
      Insecticide Resistance* ; Mosquito Vectors*/microbiology ; Mosquito Vectors*/drug effects ; Mosquito Vectors*/parasitology ; Malaria*/transmission ; Malaria*/prevention & control ; Malaria*/parasitology ; Chromobacterium*/drug effects ; Anopheles*/microbiology ; Anopheles*/parasitology ; Anopheles*/drug effects ; Insecticides*/pharmacology; Animals ; Mosquito Control/methods ; Biological Control Agents/pharmacology ; Burkina Faso ; Pest Control, Biological/methods
    • Abstract:
      Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting Anophelines has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium Chromobacterium sp. Panama ( Csp_P ) kills insecticide-resistant Anopheles mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of Csp_P acts as a synergist to now used chemical insecticides across multiple classes. Moreover, Csp_P reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione S -transferases are essential for Csp_P 's mosquito-killing mechanism. Enclosed field trials in Burkina Faso, conducted in diverse ecological settings and supported by a mathematical model, have now demonstrated its potential for malaria control in settings with widespread insecticide resistance.
    • References:
      Insects. 2021 Mar 24;12(4):. (PMID: 33804964)
      Annu Rev Entomol. 2015 Jan 7;60:537-59. (PMID: 25564745)
      Trends Parasitol. 2016 Mar;32(3):187-196. (PMID: 26826784)
      Malar J. 2013 Aug 23;12:291. (PMID: 23968494)
      PLoS Pathog. 2011 Dec;7(12):e1002458. (PMID: 22216006)
      Insects. 2023 Jun 28;14(7):. (PMID: 37504591)
      mBio. 2023 Apr 25;14(2):e0048023. (PMID: 37017525)
      Appl Environ Microbiol. 2020 May 19;86(11):. (PMID: 32220845)
      Cochrane Database Syst Rev. 2021 May 24;5:CD012776. (PMID: 34027998)
      Malar J. 2020 Feb 14;19(1):72. (PMID: 32059671)
      Nature. 2020 Jan;577(7790):376-380. (PMID: 31875852)
      Parasit Vectors. 2014 Aug 29;7:409. (PMID: 25175167)
      Front Microbiol. 2023 Feb 16;14:1040901. (PMID: 36876068)
      Nature. 2015 Oct 8;526(7572):207-211. (PMID: 26375008)
      Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
      PLoS Pathog. 2014 Oct 23;10(10):e1004398. (PMID: 25340821)
      Pestic Biochem Physiol. 2020 Jul;167:104587. (PMID: 32527435)
      Biomed Pharmacother. 2009 Feb;63(2):79-85. (PMID: 18819770)
      Chem Res Toxicol. 2001 Aug;14(8):1107-17. (PMID: 11511185)
      Parasit Vectors. 2019 Jan 6;12(1):9. (PMID: 30612581)
      Malar J. 2020 Jan 7;19(1):11. (PMID: 31910831)
      Sci Rep. 2018 Apr 18;8(1):6176. (PMID: 29670144)
      PLoS One. 2023 Jun 6;18(6):e0286679. (PMID: 37279239)
      PLoS One. 2014 Mar 27;9(3):e92662. (PMID: 24675797)
      Parasit Vectors. 2018 Apr 5;11(1):229. (PMID: 29622036)
    • Accession Number:
      0 (Insecticides)
      0 (Biological Control Agents)
    • Publication Date:
      Date Created: 20241204 Date Completed: 20241204 Latest Revision: 20241207
    • Publication Date:
      20241209
    • Accession Number:
      PMC11616681
    • Accession Number:
      10.1126/sciadv.ads3658
    • Accession Number:
      39630892