Curcuma longa rhizome extract: a potential antibiofilm agent against antibiotic-resistant foodborne pathogens.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 9200331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2454 (Electronic) Linking ISSN: 08927014 NLM ISO Abbreviation: Biofouling Subsets: MEDLINE
    • Publication Information:
      Publication: 2002- : Abingdon, Oxford : Taylor & Francis
      Original Publication: Chur ; New York : Harwood Academic Publishers, c1988-
    • Subject Terms:
      Biofilms*/drug effects ; Curcuma*/chemistry ; Plant Extracts*/pharmacology ; Plant Extracts*/chemistry ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry ; Rhizome*/chemistry ; Microbial Sensitivity Tests*; Gas Chromatography-Mass Spectrometry ; Bacteria/drug effects ; Drug Resistance, Bacterial ; Food Microbiology
    • Abstract:
      The traditional medicinal value of Curcuma longa (turmeric) and its potential relevance in modern healthcare suggests that traditional remedies and natural products can provide valuable solutions to contemporary challenges, such as combating biofilms and antibiotic-resistant pathogens, potentially offering new strategies for addressing health and safety issues in the fields of food and medicine. This study assessed the antibiofilm and antibacterial characterization of Curcuma longa rhizome extract against antibiotic-resistant foodborne pathogens. Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier-transform infrared (FTIR) analysis were determined to check for the compounds, functional groups, and constituents of the plant extract. In-vitro antibiofilm and antibacterial bioassay of the extract were determined using standard bacteriological procedures. Potential mechanisms of the plant extract were also studied using standard biological methods. The important chemical constituents from the GC-MS extract of C. longa are arturmerone, cinnamyl angelate, tumerone, γ-atlantone, atlantone, α-atlantone, γ-atlantone and curlone. The FTIR analysis of the extract comprises alkyl halides, bromoalkanes, alkanes, ethylene molecules, arenes, amines, alcohols, sulfones, carboxylic acids and their derivatives, aromatic compounds, and phenols. The MIC of C. longa crude extract ranges from ethanol extract (0.03125 - 0.5 mg/mL) and acetone extract (0.0625 - 0.5 mg/mL). The MBC range is as follows: ethanol extract (0.125 - 1 mg/mL), acetone extract (0.125 - 1 mg/mL). The time-kill kinetics showed significant cell reduction with time. The bacterial isolates' nucleic acids and protein leakage were consistent with increased extract concentration and time. There was a reduction in the biofilm cell on the shrimp surface and EPS with increased concentration and time. C. longa exerted significant anti-biofilm activity by removing existing biofilms, disrupting cell connections, and decreasing cells in biofilms. These findings can aid food protection from microbial contamination and prevent biofilms-related infections.
    • Contributed Indexing:
      Keywords: Biofilms; Curcuma longa; antibacterial; antibiofilm; antibiotic resistance; food safety
    • Accession Number:
      0 (Plant Extracts)
      0 (Anti-Bacterial Agents)
      856YO1Z64F (turmeric extract)
    • Publication Date:
      Date Created: 20241203 Date Completed: 20241211 Latest Revision: 20241211
    • Publication Date:
      20241212
    • Accession Number:
      10.1080/08927014.2024.2432963
    • Accession Number:
      39624852