Staggering cytotoxic effects of manganese oxide nanoparticles from Bacillus thuringiensis.

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  • Author(s): Aseef A;Aseef A; Venkatkumar S; Venkatkumar S
  • Source:
    Microbial pathogenesis [Microb Pathog] 2025 Jan; Vol. 198, pp. 107184. Date of Electronic Publication: 2024 Nov 28.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE
    • Publication Information:
      Original Publication: London ; Orlando : Academic Press, c1986-
    • Subject Terms:
      Manganese Compounds*/chemistry ; Manganese Compounds*/pharmacology ; Oxides*/chemistry ; Oxides*/pharmacology ; Bacillus thuringiensis*/metabolism ; Biofilms*/drug effects ; Onions* ; Nanoparticles*/chemistry ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Microscopy, Electron, Transmission ; Microscopy, Electron, Scanning ; Plant Roots/chemistry ; Microbial Sensitivity Tests ; Particle Size ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity
    • Abstract:
      The current study describes the biological synthesis of manganese oxide nanoparticles from Bacillus thuringiensis, as well as their characterization, biological activity, and toxicity. Nanoparticles may be synthesized in multiple ways, but the biogenic process is the most environmentally friendly and cost-effective. The optical, structural, and crystalline properties of the nanoparticles were investigated. A distinctive peak at 246 nm with a band gap of 3.7eV indicates manganese oxide nanoparticle production. A strong peak at 563.09 cm -1 indicates Mn-O stretching in Fourier Transform Infrared Spectroscopy analysis. X-ray diffraction revealed that the crystalline grain size of manganese oxide nanoparticles was 11.23 nm. The agglomerated spherical shape is seen in the Scanning Electron Microscope and High-Resolution Transmission Electron Microscope investigations. The presence of manganese was verified by the EDAX. Manganese oxide nanoparticles have a significant zeta potential peak of -23.4 mV. This work explored the biological activity of manganese oxide nanoparticles, including antibacterial, anti-inflammatory, antioxidant, and biofilm inhibition studies. To investigate cytotoxicity, Allium cepa root tips are treated with manganese oxide nanoparticles.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Allium cepa; Bacillus thuringiensis; Biological activity; Cytotoxicity; Manganese oxide nanoparticles
    • Accession Number:
      0 (Manganese Compounds)
      0 (Oxides)
      64J2OA7MH3 (manganese oxide)
      0 (Anti-Bacterial Agents)
      0 (Antioxidants)
    • Publication Date:
      Date Created: 20241130 Date Completed: 20241213 Latest Revision: 20241213
    • Publication Date:
      20241214
    • Accession Number:
      10.1016/j.micpath.2024.107184
    • Accession Number:
      39615705